Diabetes

Type 1 and Type 2 Research 

FINDING SOLUTIONS

Research Focus

Scharp-Lacy is devoted to developing new treatments and therapies, including islet encapsulation and islet expansion, to improve the lives of all patients who suffer from this disease.

Published Articles

  • Scharp, D.W., Arulmoli, J., Morgan, K., Sunshine, H, Hao, E – “Advances in Human Islet Processing: Manufacturing Steps to Achieve Predictable Islet Outcomes from Research Pancreases, ABM Transplantation, 2019. 3(1):1-73.
  • Lee SH, Hao E, Scharp D, Levine F: Insulin Acts as a Repressive Factor to Inhibit the Ability of PAR2 to Induce Islet Cell Trans-differentiation. Islets. 2018:1-24.
  • Markmann, JF, Bartlett ST, Johnson P, Korsgren O, Hering BJ, Scharp,D … Executive Summary of IPITA-TTS Opinion Leaders Report on Future of B-Cell Replacement. Transplantation 100 (7), e25-e31, 2018.
  • Bartlett, ST, Markmann, JF, Johnson, JF, Korsgren, O, Hering, BJ, Scharp, DW... Report from IPITA-TTS opinion leaders meeting on the future of B-cell replacement, Transplantation 100 (Suppl 2), S1, 2016.
  • Tamaki, S., Nye, C., Slorach, E., Scharp, D., Blau, H.M., Whiteley, P., Pomerantz, J.H. – “Simultaneous silencing of multiple RB and p53 pathway members induces cell cycle reentry in intact human pancreatic islets.” BMC Biotechnology 14:86, 2014.
  • Scharp, DW, Marchetti, P. “Encapsulated Islets for Diabetes Therapy: History, Current Progress, and Critical Issues Requiring Solution” Advanced Drug Delivery Reviews, 67- 68: 35-73, August, 2014.
  • Kühtreiber, WM, Ho, LT, Kamireddy, A, Yacoub, JAW, Scharp, DW –Islet Isolation From Human Pancreas With Extended Cold Ischemia Time, Transplantation Proceedings 42: 2027- 2031, 2010.
  • Mirbolooki, MR, Taylor, GE, Knutzen, VK, Scharp, DW, Willcourt, R... Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications? Medical hypotheses 73 (3), 363-369, 2009.
  • Scharp, DW, Encapsulated human islet allografts: providing safety with efficacy, Cellular Transplantation, 135-153, 2007.
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  • Coutts, M, Hinton, S, Zheng, J, Scharp, DW – Hypothermic storage and preservation of human pancreatic acinar tissue. In Vitro Cell Dev Biol 43:2-6, 2007.
  • Latta, P, Ricordi, C, Scharp, DW. Paul E Lacy, MD, PhD – February7, 1924 to February 15, 2005. Am J Transplantaion5 (5) 976-977
  • Scharp, D, Yu, X, Sheckler, V, Hubbell, J, Latta, P. – Clinically relevant results from encapsulated islet allografts implanted subcutaneously in diabetic baboons without long term immunosuppression. Diabetes 54: Sup 194-OR, 2005.
  • Cruise, G.M., Hegre, O.D., Lamberti, F.V., Hager, S.R., Hill, R., Scharp, D.W., Hubbell, J.A. - In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes, Cell Transplantation, 8:293-306, 1999
  • Cruise, G.M., Scharp, D.W., Hubbell, J.A. - Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels, Biomaterials 19:1287-1294, 1998
  • Cruise, G.M., Hegre, O.D., Scharp, D,W., Hubbell J.A., - A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylateupon porcine islets, Biotech. Bioeng. 57:655-665, 1998
  • Swanson, CJ, Olack, BJ, Flavin, KS, Mohanakumar, T, Brennan, DC ... Comparison of transplanted islets in patients with functioning versus non-functioning allografts, Transplantation proceedings 29 (4), 2241-2242,1997.
  • Olack, BJ, Swanson, CJ, Flavin, KS, Phelan, D, Brennan, DC, White, NH... Sensitization to HLA antigens in islet recipients with failing transplants, Transplantation proceedings 29 (4), 2268-2269, 1997
  • Brennan, DC, Flavin, KS, Scharp, DW, Lacy, PE, Olack, BJ, Swanson, C ... Long-term (>30 months) follow-up of a single successful kidney-islet transplant recipient, Transplantation proceedings 29 (4), 2231-2233, 1997.
  • Hill, R.S., Cruise, G.M., Hager, S.R., Lamberti, F.V., Yu, X., Garufis, C.L., Yu, Y., Mundwiler, K.E., Cole, J.F., Hubbell, J.A., Hegre, O.D., Scharp, D.W. - Immunoisolation of adult porcine islets for the treatment of diabetes mellitus, Annals of the NY Academy of Sciences 831:332-343, 1997
  • Shiroki R, Nazirrudin,D, Hoshinaga,K, Naide, Y, Scharp, DW. Human Peripheral blood lymphocyte-reconstituted, severe combined Immunodeficiency Mice as a model for porcine islet xenograft rejection in humans. Artificial Organs 20 (8) 878-882. 1996
  • Marchetti, P., Scharp, D.W., Finke, E.H., Swanson, C.J., Olack, B.J., Gerasimidi-Vazeou, A., Giannarelli, R., Navalesi, R., Lacy, P.E. - Prolonged survival of discordant porcine islet xenografts, Transplantation 61:1100-1102, 1996
  • Atkison, PR, Zucker, P, Hramiak, I, Paul, TL, Dupre, J, Behme, MT...Continued insulin dependence despite normal range insulin sensitivity and insulin connecting peptide levels in a kidney/islet transplant patient, Diabetes Care 19 (3), 236-240, 1996.
  • Marchetti, P, Scharp, DW, Giannarelli, R, Benzi, L, Cicchetti, P, Ciccarone, A... Metformin potentiates glucose-stimulated insulin secretion, Diabetes Care 19, 781-782, 1996.
  • Davali GC, Scharp, DW, A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice, Transplantation 59 (6), 817-820, 1995.
  • Borge, MA, Scharp, DW, Picus, D, Percutaneous ablation of a pancreatic remnant with intraductal injection of neoprene, Journal of Vascular and Interventional Radiology 6 (5), 762-764, 1995.
  • P Marchetti, DW Scharp, M McLear, EH Finke, B Olack, C Swanson, ... , Insujlin inhibits its own secretion from isolated, perifused human pancreatic islets, Acta diabetologica 32 (2), 75-77, 1995.
  • Perdrizet, GA, Rewinski, MJ, Bartus, SA, Hull, D, Schweizer, RT, Scharp, DW, Albumin improves islet isolation: specific versus non-specific effects, Transplantation proceedings 27 (6), 3400-3402, 1995.
  • Marchetti, P., Scharp, D.W., Finke, E.H., Swanson, C.J., Olack, B.J., Gerasimidi-Vazeou, A., Giannarelli, R., Navalesi, R., Lacy, P.E. - Prolonged survival of discordant porcine islet xenografts, Transplantation 61:1100-1102, 1996
  • Atkison, PR, Zucker, P, Hramiak, I, Paul, TL, Dupre, J, Behme, MT...Continued insulin dependence despite normal range insulin sensitivity and insulin connecting peptide levels in a kidney/islet transplant patient, Diabetes Care 19 (3), 236-240, 1996.
  • Marchetti, P, Scharp, DW, Giannarelli, R, Benzi, L, Cicchetti, P, Ciccarone, A... Metformin potentiates glucose-stimulated insulin secretion, Diabetes Care 19, 781-782, 1996.
  • Davali GC, Scharp, DW, A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice, Transplantation 59 (6), 817-820, 1995.
  • Borge, MA, Scharp, DW, Picus, D, Percutaneous ablation of a pancreatic remnant with intraductal injection of neoprene, Journal of Vascular and Interventional Radiology 6 (5), 762-764, 1995.
  • P Marchetti, DW Scharp, M McLear, EH Finke, B Olack, C Swanson, ... , Insujlin inhibits its own secretion from isolated, perifused human pancreatic islets, Acta diabetologica 32 (2), 75-77, 1995.
  • Shiroki, R, Mohanakumar, T, Scharp, DW, Analysis of the serological and cellular sensitization induced by encapsulated human islets transplantation in type 1 and the 2 diabetes patients, Cell transplantation 4 (5), 535-538, 1995
  • Perdrizet, GA, Rewinski, MJ, Bartus, SA, Hull, D, Schweizer, RT, Scharp, DW, Albumin improves islet isolation: specific versus non-specific effects, Transplantation proceedings 27 (6), 3400-3402, 1995.
  • Shiroki, R, Mohanakumar, T, Scharp, DW, Analysis of the serological and cellular sensitization induced by encapsulated human islets transplantation in type 1 and the 2 diabetes patients, Cell transplantation 4 (5), 535-538, 1995
  • Chern, H.T., Scharp, D.W. - Successful long-term cryopreservation of highly purified canine islets, European Surg Res 27:167-175, 1995
  • Brennan, D.C., Scharp, D.W., White, N.H., Flavin, K.S., Zukosky, J.M., Ansara, M.F., Cryer, P.E., Lacy, P.E. - Modification of methodology results in improvements in simultaneous kidney-islet success, Transplant Proc. 27(1):1349-1350, 1995
  • Marchetti, P, Scharp, DW, Lacy, PE, Navalesi, R, Long-term survival of pig-to-mouse islet xenografts, Xenotransplantation 2 (3), 154-156, 1995.
  • Ansara, M.F., Saudek, F., Newton, M., Cryer, P.E., Scharp, D.W. - Pancreatic islet transplantation prevents defective glucose counter-regulation in diabetic dogs, Transplant Proc. 26(2):664-665, 1994
  • Ansara, M.F., Saudek, F., Newton, M., Cryer, P.E., Scharp, D.W. - Pancreatic islet transplantation prevents defective glucose counter-regulation in diabetic dogs, Transplant Proc. 26(2):664-665, 1994
  • Scharp, DW, Gingerich, R, Giannarelli, RL Ansara, M, Olack, BJ ... Insulin and glucagon release from isolated, perifused human islets following low-temperature culture and cryopreservation, Transplantation proceedings 26 (2), 821-822, 1994.
  • Shiroki, R., Poindexter, N., Mohanakumar, T., Scharp, D.W. - Rejection of human islet allografts in human lymphocyte-reconstituted severe combined immunodeficient mice, Transplant Proc. 26(2):716-717, 1994
  • Barnett, D.W., Pressel, D.M., Chern, H.T., Scharp, D.W., Misler, S. - cAMP-Enhancing agents “permit” stimulus-secretion coupling in canine pancreatic islet ß-cells, J. Membrane Biol 138:113-120, 1994
  • Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Effect of different temporary immunosuppressive therapies and low-temperature culture on pancreatic islet xenograft survival (Pig-to-Mouse), Transplant Proc. 26(2):760-761, 1994
  • Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Effect of different temporary immunosuppressive therapies and low-temperature culture on pancreatic islet xenograft survival (Pig-to-Mouse), Transplant Proc. 26(2):760-761, 1994
  • Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Anti-CD4 antibody treatment in xenografts of differently immunomodulated porcine islets, Transplant Proc. 26(3):1132, 1994
  • Perdrizet, G.A., Rewinski, M.J., Schweizer, R.T., Scharp, D.W. - Heat shock and recovery protects pancreatic islets from warm ischemic injury, Transplant Proc. 26(6) 3477-3478, 1994
  • di Carlo, A., Scharp, D.W., Gingerich, R.L., Ansara, M.F., Olack, B.J., Swanson, C.J., Giannarelli, R., Navalesi, R. - C-peptide secretion from isolated perifused human islets: effect of culture and cryopreservation, Transplant Proc. 26(6) 3399, 1994
  • Marchetti, P., Scharp, D.W., Finke, E.H., Giannarelli, R., Swanson, C.J., Olack, B.J., Lacy, P.E., Navalesi, R. - Factors affecting in vitro and in vivo function of isolated porcine islets, Transplant Proc. 26(6):3419-3420, 1994
  • Scharp, D.W., Swanson, C.J., Olack, B.J., Latta, P.P., Hegre, O.D., Doherty, E.J., Gentile, F.T., Flavin, K.S., Ansara, M.F., Lacy, P.E. - Protection of encapsulated human islets implanted without immunosuppression in patients with Type I and Type II diabetes and in non-diabetic controls, Diabetes 43:1167, 1994
  • Shiroki, R, Poindexter, NJ, Mohanakumar, T, Scharp, DW, Rejection of human islet allografts in human lymphocyte-reconstituted severe combined immunodeficient mice, Transplantation proceedings 26 (2), 716-717, 1994.
  • Shiroki, R., Poindexter, N.J., Woodle, E.S., Hussain, M.S., Mohanakumar, T., Scharp, D.W. - Human peripheral blood lymphocyte reconstituted severe combined I mmunodeficient (hu-PBL-SCID) mice: a model for human islet allograft rejection, Transplantation 58:1555-1562, 1994
  • Marchetti, P., Scharp, D.W., McLear, M., Gingerich, R., Finke, E.H., Olack, B.J., Swanson, C.J., Giannarelli, R., Navalesi, R., Lacy, P.E. - Pulsatile insulin secretion from isolated human pancreatic islets, Diabetes 43:827-830, 1994
  • Marchetti, P., Kneteman, N.M., Swanson, C.J., Olack, B.J., Scharp, D.W. - Effect of cyclosporin treatment on metabolic and hormonal responses to mixed meal plus oral glucose in dogs with intrasplenic pancreatic islet autograft, Experimental Medicine
  • Marchetti, P, Scharp, DW, Pfifner, K Cryogenic storage of isolated, purified porcine pancreatic islets, Transplantation 57:340-346, 1994
  • Marchetti, P., Scharp, D.W., Pfiffner, K., Swanson, C.J., Finke, E.H., Olack, B.J., Gerasimidi-Vazeou, A., McLear, M., Lacy, P.E. - Cryogenic storage of isolated, purified porcine pancreatic islets, Transplantation 57:340-346, 1994
  • di Carlo, A., Scharp, D.W., Gingerich, R.L., Giannarelli, R., Ansara, M., Olack, B.J., Swanson, C.J., Navalesi, R. - Insulin and glucagon release from isolated, perifused human islets following low- temperature culture and cryopreservation, Transplant Proc. 26(2):821-822, 1994
  • Scharp, DW.Production of marked prolongation of Survival of Canine Islet Xenografts in Mice by anti-lymphocyte sera and L3T4 Antibody. Transplantation . 52(6) 1094-1096
  • Marchetti, P., Olack, B., Swanson, C., Newton, M., Scharp, D.W. - Assessment of longterm (1 year) graft survival and metabolic hormonal changes after intrasplenic canine pancreatic microfragment transplantation, Diabetes & Metabolism 19:17-24, 1993
  • Brelje, TC, Scharp, DW, Lacy, PE, Ogren, L, Talamantes, F, Robertson, M... Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets, Endocrinology 132 (2), 879-887,1993
  • Marchetti, P., Scharp, D.W., Olack, B.J., Swanson, C.J., Bier, D., Colelli, C., Toffolo, G., Newton, M., Navalesi, R. - Glucose metabolism, insulin sensitivity and glucagon secretion in dogs with intraportal or intrasplenic islet autografts, Transplant Proc 24(6):2828-2829, 1992
  • Marchetti, P., Pfiffner, K., Scharp, D.W., Lacy, P.E., Gerasimidi-Vazeou, A., Finke, E.H. - Successful cryopreservation of porcine pancreatic islets, Transplant Proc 24(3):1005- 1006, 1992
  • Porte, D, Baker, L, Bollinger, R, Genuth, S, Scharp, DW, Sutherland, DRW, Pancreas transplantation for patients with diabetes mellitus, Diabetes Care 15 (11), 1673, 1992
  • Marchetti, P., Finke, E.H., Swanson, C., Gerasimidi-Vazeou, A., Olack, B., Scharp, D.W., Navalesi, R., Lacy, P.E. - The potential of porcine islet xenotransplantation in the therapy of diabetes, Diab. Nutr. Metab. 5 (Suppl 1):151-154, 1992
  • Kneteman, N.M., Marchetti, P., Tordjman, K., Bier, D.M., Santiago, J.V., Swanson, C.J., Olack, B.J., Scharp, D.W. - Effect of cyclosporine on insulin secretion and insulin sensitivity in dogs with intrasplenic islet autotransplants, Surgery 111(4):430-437, 1992
  • Olack, B.J., Hill, A., Scharp, D.W., Lacy, P.E. - Automated purification of canine islets, Transplant Proc 24(3):1003-1004, 1992
  • Scharp, D.W., Marchetti, P., Swanson, C.J., Newton, M., McCullough, C.S., Olack, B.J. - The effect of transplantation site and islet mass on long-term survival and metabolic and hormonal function of canine purified islet autografts, Cell Transplantation 1:245- 254, 1992
  • McLear, M., Marchetti, P., Finke, E., Gerasimidi-Vazeou, A., Scharp, D.W., Lacy, P.E. - Porcine islet function: Effects of arginine, Leucine, and Butyrate, Transplant Proc 24(3):980-982, 1992
  • Marchetti, P., Swanson, C., McLear, M., Finke, E.H., Gerasimidi-Vazeou, A., Scharp, D.W., Lacy, P.E. - In vitro function and xenotransplantation of long-term (3 weeks) cultured porcine islets of Langerhans, Transplant Proc 24(2):637, 1992
  • Misler, S. Barnett, D.W., Pressel, D.M., Gillis, K.D., Scharp, D.W., Falke, L.C. - Stimulussecretion coupling in B cells of transplantable human islets of Langerhans: evidence for a critical role in Ca2+ entry. Diabetes 41 (6), 662-670, 1992
  • Marchetti, P., Scharp, D.W., Longwith, J.E., Swanson, C.J., Olack, B.J., GerasimidiVazeou, A., Finke, E.H., Lacy, P.E. - Prevention of contamination of isolated porcine islets of Langerhans, Transplantation 53(6):1364-1366, 1992
  • Scharp, D.W., Lacy, P.E., McLear, M., Longwith, J.E., Olack, B.J. - The bioburden of 590 consecutive human pancreata for islet transplant research, Transplant Proc 24(3):974- 975, 1992
  • Marchetti, P., Finke, E.H., Swanson, C., Gerasimidi-Vazeou, A., Olack, B., Scharp, D.W., Navalesi, R., Lacy, P.E. - The potential of porcine islet xenotransplantation in the therapy of diabetes, Diab. Nutr. Metab. 5 (Suppl 1):151-154, 1992
  • Olack, B., Swanson, C., McLear, M., Longwith, J., Scharp, D.W., Lacy, P.E. - Islet purification using Euroficoll gradients, Transplant Proc 23(1):774-776, 1991
  • Falqui, L., Finke, E.H., Carel, J.C., Scharp, D.W., Lacy, P.E. - Marked prolongation of human islet xenograft survival (human to mouse) by low-temperature culture and temporary immunosuppression with human and mouse anti-lymphocyte sera, Transplantation 51:1322-1324, 1991
  • Marchetti, P., Finke, E.H., Gerasimidi-Vazeou, A., Falqui, L., Scharp, D.W., Lacy P.E.- Automated large scale isolation, in vitro function and xenotransplantation of porcine islets of Langerhans, Transplantation 52:209-213, 1991
  • Scharp, D.W., Lacy P.E. - The clinical feasibility of human islet transplantation, Clinical Diabetes 42- 45, May/June, 1991
  • Falqui, L., Finke, E.H., Carel, J.C., Scharp, D.W., Lacy, P.E. - Marked prolongation of human islet xenograft survival (human to mouse) by low-temperature culture and temporary immunosuppression with human and mouse anti-lymphocyte sera, Transplantation 51:1322-1324, 1991
  • Scharp, D.W., Lacy, P.E., Weide, L.G., Marchetti, P., McCullough, C.S., Flavin, K., Santiago, J.V. - Intraportal islet allografts: the use of a stimulation index to represent functional results, Transplant Proc 23(1):796-798, 1991
  • Finke, E., Marchetti, P., Falqui, L., Swanson, C., McLear, M., Olack, B., Scharp, D.W., Lacy, P.E. - Large scale isolation, function and transplantation of islets of Langerhans from the adult pig pancreas, Transplant Proc 23(1):772-773, 1991.
  • Lacy, PE, Scharp, DW, Prevention of rejection of islet allografts and xenografts without continuous immunosuppression of the recipients, Organ Transplantation 1990, 397- 404, 1991.
  • Scharp, D.W., Lacy, P.E., Santiago, J.V., McCullough, C.S., Weide, L.G., Boyle, P.J., Falqui, L., Marchetti, P., Ricordi, C., Gingerich, R.L., Jaffe, A.S., Cryer, P.E., Hanto, D.W., Anderson, C.B., Flye, M.W., - Results of our first nine intraportal islet allografts in Type 1, insulin-dependent diabetic patients, Transplantation 51:76-85, 1991
  • Atkinson, M.A., Holmes, L.H., Scharp, D.W., Lacy, P.E., Maclaren, N.K. - No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes, J Clin Invest 87:721-724, 1991
  • Kowalski, L., Falqui, L., Lacy, P.E., Scharp, D.W. - Production of marked prolongation of survival of canine islet xenografts in mice by antilymphocyte sera and L3T4 antibody, Transplantation 52:1094- 1097, 1991
  • Atkinson, M.A., Maclaren, N.K., Holmes, L., Scharp, D.W., Lacy, P.E., Riley, W.J. - The natural history and predictive value of Mr 64,000 autoantibodies for insulin-dependent diabetes mellitus, J Autoimmunity 3:41-45, 1990
  • Ricordi, C., Gray, D.W.R., Hering, B.J., et al - Islet isolation assessment in man and large animals, Acta Diabetoal. Lat. 27:185-195, 1990
  • Atkinson, M.A., Maclaren, N.K., Riley, W.J., Scharp, D.W., Lacy, P.E. – The Natural History and Predictive Value of 64,000 Mr autoantibodies as predictors of insulin dependent diabetes, Lancet 335:1357-1360, 1990
  • Kämpe, O, Velloso, L, Andersson, A, Karlsson, A, Atkinson, MA, Maclaren, NK, Scharp, DW ... No role of 65 kD heat-shock protein in diabetes. The Lancet 336 (8725), 1250- 1251, 1990.
  • Scharp, D.W., Lacy, P.E., Santiago, J.V., McCullough, C.S., Weide, L.G., Falqui, L., Marchetti, P., Gingerich, R.L., Jaffe, A.S., Cryer, P.E., Anderson, C.B., Flye, M.W. - Insulin independence after islet transplantation into Type 1 diabetic patient, Diabetes 39:515-518, 1990
  • Callery, M.P., Kamei, T., Flye, M.W., Davis, C.G., Swanson, C.J., Olack, B.J., Lacy, P.E., Scharp, D.W. - Intrahepatic islet autografts in dogs function despite completely diverting portacaval shunt, Transplant Proc 22:767-770, 1990
  • Kneteman, NM, Cattral, MC, Warnock, GL, Scharp, DW, Jaspan, JL ... Immunosuppression and pancreatic islet transplantation, Hormone and metabolic research. Supplement series 25, 193-199, 1990.
  • Medoff, G., Sagal, S., Krogstad, D., Peters, M., Hogan, J., Scharp, D. - Clinical Pathology Conference - Abdominal pain, fever, and weight loss in a 61 year-old Arabian Man, Am J Medicine 89:83-90, 1990
  • Chern, H.T., Scharp, D.W. - Viability assessment of cryopreserved canine islets in vivo, Endocrine Surgery 7(3):355-360, 1990
  • Scharp, D.W., Olack, B.J., Swanson, C.J., Marchetti, P. - Normal reproductive function in dogs with islet autograft, Transplant Proc 22(5):2403-2404, 1990
  • Permutt, M.A., Koranyi, L., Keller, K., Lacy, P.E., Scharp, D.W., Mueckler, M. - Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA, Proc Natl Acad Sci USA 86:8688- 8692, 1989
  • Dotta, F., Colman, P.G., Nayak, R.C., Lombardi, D., Scharp, D.W., Andreani, D., Pontieri, G.M., di Mario, U., Lenti, L., Eisenbarth, G.S. - Ganglioside expression in human pancreatic islets, Diabetes 38:1478-1483, 1989
  • Callery, M.P., Ricordi, C., Scharp, D.W., Kamei, T., Swanson, C.J., Lacy, P.E., Flye, M.W. - Hepatic insufficiency following portacaval shunting is prevented by prior intraportal pancreatic islet autotransplantation. Surgery 106:257-266, 1989
  • Schmidt, R.E., Plurad, S.B., Olack, B.J., Scharp, D.W. - The effect of pancreatic islet t ransplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic Streptozotocin diabetic rats, Brian Research 497:393-398, 1989
  • Brelje, T.C., Scharp, D.W., Sorenson, R.L. - Three-dimensional imaging of intact, isolated islets of Langerhans using Confocal microscopy, Diabetes 38:808-814, 1989
  • Kneteman, N.M., Alderson, D., Scharp, D.W., Lacy, P.E. - Long-term cryogenic storage of purified adult human islets of Langerhans, Diabetes 38:386-396, 1989
  • Kneteman, N.M., Alderson, D., Scharp, D.W., Lacy, P.E. - Prolonged cyropreservation of purified human pancreatic islets, Diabetes 38:176-178, 1989
  • Ricordi, C., Lacy, P.E., Scharp, D.W. - Automated islet isolation from human pancreas, Diabetes 38 (Suppl. 1):140-142, 1989
  • Scharp, D.W. - Islet Transplantation, Diabetes 38: (Suppl. 1):323-325, 1989
  • Scharp, D.W., Lacy, P.E., Ricordi, C., Boyle, P., Santiago, J., Cryer, P., Gingerich, R., Jaffe, A., Anderson, C.B., Flye, M.W. - Human islet transplantation in patients with Type 1 diabetes, Transplant Proc 21 (No. 1):2744-2745, February 1989
  • Misler, S., Gee, W.M., Gillis, K.D., Scharp, D.W., Falke, L.C. - A metabolite-regulated ATPsensitive K+ channel in human pancreatic islet cells, Diabetes 38:422-427, 1989
  • Kneteman, NM, Alderson,D, Scharp, DW, Lacy, PE. Long-term mass storage of purified human pancreatic islets, Transplantation proceedings 20 (5), 1023-1025, 1988.
  • Ricordi, C., Kneteman, N.M., Scharp, D.W., Lacy, P.E. - Transplantation of cryopreserved human pancreatic islets into diabetic nude mice, World J. Surgery 12:861-865, 1988
  • Corlett, M.P., Scharp, D.W. - The effect of pancreatic warm ischemia on islet isolation in rats and dogs, J. Surg. Research, 45:531-536, 1988
  • Ricordi, C., Scharp, D.W., Lacy, P.E. - Mass isolation of human pancreatic islets for transplantation. Proceedings from XXVI World Congress of the International College of Surgeons, Milan, Italy, July 3- 9, 1988, Monduzzi Editore S.p.A.
  • Ricordi, C., Scharp, D.W., Lacy, P.E. - Reversal of diabetes in nude mice after transplantation of fresh and 7 day cultured (24°C) human pancreatic islets, Transplantation 45:994-996, 1988
  • Corlett, M.P., Scharp, D.W., Lacy, P.E. - Microbial contamination risks in human islet isolation, Transplant Proc 20 (Suppl. 1):894-895, 1988
  • Corlett, M.P., Alderson, D., Kneteman, N.M., Scharp, D.W. - Long-term normoglycemia in canine islet autografts, Transplant Proc 20 (Suppl. 1):896-897, 1988
  • Turk, J., Hughes, J.H., Easom, R.A., Wolf, B.A., Scharp, D.W., Lacy, P.E., McDaniel, M.L. - Arachidonic acid metabolism and insulin secretion by isolated human pancreatic islets, Diabetes 37:992-996, 1988
  • Ricordi, C., Lacy, P.E., Finke, E.H., Olack, B.J., Scharp, D.W. - Automated method for isolation of human pancreatic islets, Diabetes 37:413-420, 1988
  • Fonseca, P., Scharp, D.W. - Use of oxygen free radical scavengers to increase the yields of isolated rat islets after pancreatic warm ischemia, Surgical Forum 38:371-373, 1987
  • Kneteman, N.M., Alderson, D., Scharp, D.W. - Long-term normoglycemia in pancreatectomized dogs following pancreatic islet allotransplantation and cyclosporine immunosuppression, Transplantation 44(5):595-599, 1987
  • Scharp, D.W., Lacy, P.E., Finke, E., Olack, B.J. - Low-temperature culture of human islets isolated by the distention method and purified with Ficoll or Percoll gradients, Surgery 102:869-879, 1987
  • Greider, MH, Scharp, DW, Gingerich, RL, Enhanced preservation of endosecretory granules in PP-cells of the canine pancreas. Regulatory peptides 18 (5-6), 299-306, 1987.
  • Kneteman, N.M., Alderson, D., Scharp, D.W. - The isolation and purification of human pancreatic islets, Transplant Proc. 19(4):3469-3470, 1987
  • Alderson, D., Kneteman, N.M., Olack, B.J., Scharp, D.W. - Isolation and quantification of canine islet tissue for transplantation, Transplantation 43(4):579-581, 1987
  • Scharp, D.W., Alderson, D., Kneteman, N.M. - The effect of immunosuppression on islet transplant function in the dog, Transplant Proc. 19(1) 952-953, 1987
  • Hymer, W.C., Scharp, D.W., et al. - Continuous flow electrophoretic separation of proteins and cells from mammalian tissues, Cell Biophysics 10:61-85, 1987
  • Alderson, D., Kneteman, N.M., Scharp, D.W. - The isolation of purified human islets of Langerhans, Transplant Proc. 19(1):916-917, 1987
  • Kneteman, N.M., Alderson, D., Scharp, D.W. - Cyclosporine A immunosuppression of allotransplanted canine pancreatic islets, Transplant. Proc., 19(1):950-951, 1987
  • Scharp, D.W., Alderson, D., Kneteman, N.M. - Optimization of islet preparations for clinical transplantation. Transplant Proc. 18(6):1814-1816, 1986
  • Scharp, D.W., Lacy, P.E., Alderson, D., Kneteman, N.M. - The procurement and distribution of cadaver human pancreas for islet isolation and transplantation. The Use of Human Tissues and Organs for Research and Transplant: Proceedings of the Second I nternational Conference: National Diabetes Research Interchange April 1986:61-70
  • Downing, R., Morrissey, S., Kiske, D., Scharp, D.W. - Does the purity of intraportal islet isografts affect their endocrine function?, J. Surg. Research 41(1):41-46, 1986
  • Scharp, DW, Long, J, Feldmeier, M, Olack, B, O’Shaughnessy, Swansonm, C. Automated Methods of Mass Islet Isolation. Methods in Diabetes Research 1 (Part C), 225-236. 1985
  • Martin, K.W., Morian, J.P., Jr., Lee, J.K.T., Scharp, D.W. - Demonstration of splenic artery pseudoaneurysm by Magnetic Resonance Imaging, J. of Computer Assisted Tomography 9(1):190- 192, 1985
  • Heiken, J.P., Balfe, D.M., Picus, D., Scharp, D.W. - Radical pancreatectomy: Postoperative evaluation by CT, Radiology 153:211-215, 1984
  • Sparks, RE, Mason, NS, Scharp, DW, Some Present Directions in Research on Tissue Transplantation Chambers, Biomaterials in Artificial Organs, 193-199, 1984.
  • Scharp, D.W. - Clinical feasibility of islet transplantation, Transplant Proc. 16(3):820-825, 1984
  • Scharp, D.W., Mason, N.S., Sparks, R.E. - Islet immunoisolation: the use of hybrid artificial organs to prevent islet tissue rejection, World J. of Surgery 8:221-229, 1984
  • Scharp, DW, Transplantation of pancreatic islet cells – Introduction, World Journal of Surgery 8 (2), 135-136, 1984
  • Scharp, D.W. - Isolation and transplantation of islet tissue, World J. of Surgery 8:143- 151,1984
  • Giddings, S.J., Rotwein, P., Chirgwin, J.M., Scharp, D.W., Permutt, M.A. - Analysis of insulin gene expression in human pancreas, Diabetes 32:777-780, 1983
  • Schmidt, R.E., Santiago, B.P., Olack, B.J., Scharp, D.W. - The effect of pancreatic islet t ransplantation and insulin therapy on experimental diabetic autonomic neuropathy, Diabetes 32:532- 540, 1983
  • Sparks, RE, Mason, TC, Scharp, DW, A distributed source-model for the hybrid artificial pancreas, ASAIO Journal 29 (1), 460-462, 1983.
  • Long, J.A., Britt, L.D., Olack, B.J., Scharp, D.W. - Autotransplantation of isolated canine islets, Transplant Proc. 15:1332-1338, 1983
  • Scharp, D.W., Long, J.A. - Studies of islet isolation and transplantation, Cryobiology 20:129-137, 1983
  • Scharp, DW, Long, JA, Olack, BA, Preparation of pseudo-islets, Cryobiology 19 (6), 659- 660, 1982.
  • Scharp, DW, Lacy, PE, The isolation and alteration of islet tissue for transplantation. In Vitro – Journal of the Tissue Culture Association. 18 (3), 316-317, 1982.
  • Britt, L.D., Scharp, D.W., Lacy, P.E., Slavin, S., Transplantation of islet cells across major histocompatibility barriers after total lymphoid irradiation and infusion of allogeneric bone marrow cells, Diabetes 31 Aupp 4), 63-68, 1982.
  • Gingerich, R.L., Scharp, D.W., Grieder, M.H., Dye, E.S., Mousel, K.A. - A new in vitro model for studies of pancreatic polypeptide secretion and biochemistry, Regulatory Peptides 5:13-25, 1982
  • Sparks, R.E., Mason, N.S., Finley, T.C., Scharp, D.W., Development, testing, and modeling of an islet transplantation chamber, ASAIO Journal 28 91), 229-231, 1982.
  • Yasunami, Y., Lacy, P.E., Scharp, D.W., Britt, L.D. - Isolation and transplantation of islet cells from the neonatal pig pancreas, Surgical Forum 33, 359-361, 1982
  • Schmidt, R.E., Scharp, D.W. - Axonal dystrophy in experimental diabetic autonomic neuropathy, Diabetes 31:761-770, 1982
  • Greider, MH, Gingerich, RL, Scharp, DW, in vitro studies of canine pseudo-islets, Cellular Basis of Chemical Messengers in the Digestive System, 317-321, 1981
  • Paquette, T.L., Gingerich, R., Scharp, D.W. - Altered amidation of pancreatic polypeptide in culture, Biochemistry 20:7403-7408, 1981
  • Scharp, DW, Rejection of islet isografts in a strain of Lewis rats, Transplantation 31 (3) 229- 230, 1981.
  • Bergen, J., Mason, N.S., Scharp, D.W., Sparks, R.E. - Insulin inhibition of islets in transplantation chambers, Artificial Organs 5:787-791, 1981
  • Britt, L.D., Scharp, D.W., Lacy, P.E., Slavin, S. - Transplantation of islet cells across major histocompatibility barriers after total lymphoid irradiation and infusion of allogeneic bone marrow cells, Diabetes 31:36-38, 1982
  • Silberberg,R, Scharp, DW, LEsker, PA. Biochemical Studies of Long Bone from Diabetic Rats and Rats Bearing Transplanted Pancreatic Islets.,Pathobiology 49(2) 61-67.
  • Britt, L.D., Stojeba, P.C., Scharp, C.R., Grieder, M.H., Scharp, D.W. - Neonatal pig pseudoislets: A product of selective aggregation, Diabetes 30:580-583, 1981
  • Britt, L.D., Stojeba, P.C., Scharp, C.R., Grieder, M.H., Scharp, D.W. - Neonatal pig pseudoislets: A product of selective aggregation, Diabetes 30:580-583, 1981
  • Rajotte, R.V., Scharp, D.W., Downing, R., Preston, R., Molnar, G.D., Ballinger, W.F. - Pancreatic islet banking: the transplantation of frozen-thawed rat islets transported between Centers, Cryobiology 18:357-369, 1981
  • Silberberg, R., Scharp, D.W., Lesker, P.A. - Biochemical studies of bone from diabetic rats and rats bearing transplanted pancreatic islets, Experimental Cell Biology 49:61-67, 1981
  • RV Rajotte, DW Scharp, R Downing, P Preston, GD Molnar, WF Ballinger, Transplantation of frozen-thawed rat islets of Lanagerhans after sucrose versus step dilution, Cryobiology 17 (6), 618-619, 1981.
  • Grieder, M.H., Gingerich, R.L., Scharp, D.W. - In Vitro studies of canine pseudo-islets. UCLA Symposium - Cellular Basis of Chemical Messengers in the Digestive System”, Los Angeles, January 16-18, 1980
  • Downing, R., Scharp, D.W., Ballinger, W.F., An improved technique for the isolation and identification of mammalian islets of Langerhans, Transplantation 29(1), 79.82, 1980.
  • Feldman, S.D., Scharp, D.W., Lacy, P.E., Ballinger, W.F. - Fetal pancreas isografts, cultured and uncultured, to reverse streptozotocin induced diabetes mellitus, J. Surgical Research 29:309-318, 1980
  • Merrell, R.C., Scharp, D.W., Gingerich, R., Feldmeier, M.M., Grieder, M., Downing, R. - New approaches to the separation of islet cells, Surgical Forum 30:303-305, 1979
  • Downing, R., Scharp, D.W., Merrell, R.C., Grieder, M., Ballinger, W.F. - Venous versus ductal distension of the dog pancreas for isolation of islets, Surgical Forum 30:422-424, 1979
  • Scharp, D.W., Downing, R., Merrell, R.C., Grieder, M. - Isolating the elusive islet, Diabetes 29(1):19- 30, 1980
  • Lacy, P.E., Davie, J.M., Finke, E.H., Scharp, D.W. - Prolongation of islet allograft survival, Transplantation 27:171-174, 1979
  • Downing, R., Scharp, D.W., Ballinger, W.F. - An improved technique for the isolation and identification of mammalian islets of Langerhans, Transplantation 29:79-83, 1980
  • Merrell, RC, Scharp, DW, Gingerich, R, Feldmeier, M, Greider, M, Downing, R. New Approaches to Separation of Islet Cells. Surgical Forum 30. 301-305, 1978.
  • Downing, R., Scharp, D.W., Merrell, R., Greideer, M., Ballinger, W.F. Venous versus ductal distension of the canine pancreas for isolation of islets, Surgical Forum 30:422-424, 1979.
  • Scharp,DW, Merrell, RC, Feldmeier, MM, Downing, R, Ballinger, WG.Pseudo-islet Formation and Culture from Canine Isolated Pancreatic Cells. InVitro Journal Tissue Culture Association 15(3) 216, 1979
  • Krupin, T., Waltman, S.R., Scharp, D.W., Oestrich, G., Feldman, S.D., Becker, D., Ballinger, W.F., Lacy, P.E. - Ocular fluorophotometry in experimental diabetes mellitus: The effect of pancreatic islet isografts, Investigative Ophthalmology & Visual Science 18:1185-190, 1979
  • Scharp, D, Krupin, T, Waltman, S, Oestrich, C, Feldman, S, Ballinger, W ... Relationship of abnormal insulin release to fluorophotometry in experimental diabetes, Diabetes 27, 435-435, 1978.
  • Scharp, D, Krupin, T, Waltman, S, Oestrich, C, Feldman, S, Ballinger, W ... Relationship of abnormal insulin release to fluorophotometry in experimental diabetes, Diabetes 27, 435-435, 1978.
  • Scharp, D.W., Merrell, R.C., Feldman, S.D., Downing, R., Lacy P,E., Ballinger, W. - The use of gyrotational culture for the preservation of isolated islets, Surgical Forum 29:100- 102, 1978
  • Feldman, S, Dodi, G, Haid, K, Scharp, DW, Ballinger, WF, Lacy, PE, Artificial hybrid pancreas, Surgical Forum 28:439-441, 1977
  • Feldman, S., Scharp, D., Hirshberg, G., Dodi, G., Ballinger, W., Lacy, P.E. - Streptozotocininduced liver tumors, Transplantation 24:152-154, 1977
  • Griffith, R.C., Scharp, D.W., Hartman, B.K., Ballinger, W.F., Lacy, P.E. - A morphologic study of intrahepatic portal vein islet isografts, Diabetes 26:201-214, 1977
  • Scharp, DW, Merrell, RC, Feldman SD, Ruwe, EA, Feldmeier, M. Long-Term Culture of Islets of Langerhans Utilizing a Rotational Culture Method. In Vitro- Journal of Tissue Culture Association.13 (3), 174.
  • Karl, R.C., Scharp, D.W., Ballinger, W.F., Lacy, P.E. - Transplantation of insulin-secreting tissues, J British Society Gastroenterology - GUT 18:1062-1072, 1977
  • Feldman, S., Hirshberg, G., Dodi, G., Raizman, M., Scharp, D., Ballinger, W., Lacy, P.E. - Intrasplenic islet isografts, Surgery 82:386-394, 1977
  • Scharp, D.W., Murphy, J.J., Newton, W.T., Ballinger, W.F., Lacy, P.E. - Application of an improved isolation technique for islet transplantation in primates and rats, Transplant. Proc. 6(1):739-741, 1975
  • Scharp, D.W., Murphy, J.J., Newton, W.T., Ballinger, W.F., Lacy, P.E. - Transplantation of islets of Langerhans in diabetic Rhesus monkeys, Surgery 77:100-105, 1975
  • MJ Knight, DW Scharp, CB Kemp, SB Nunnelly, Ballinger WF, PE Lacy, Cryopreservation of pancreatic islets. European Surgical Research, 6, 89-89, 1974.
  • DW Scharp, CB Kemp, MJ Knight, JJ Murphy, WT Newton, WF Ballinger, ... Long-term results of portal vein islet isografts and allografts in treatment of streptozotocin-induced diabetes, Diabetes 23, 359-359, 1974.
  • Ballinger, WF, Lacy, PE, Scharp. DW, Kemp, CB, Knight, M- Isografts and Allografts of Pancreatic Islets in Rats. British J Surgery, 60(4): 313, 1973
  • Ballinger, WF, Lacy, PE, Scharp. DW, Kemp, CB, Knight, M- Isografts and Allografts of Pancreatic Islets in Rats. British J Surgery, 60(4): 313, 1973
  • Kemp, C.B., Knight, M.J., Scharp, D.W., Ballinger, W.F., Lacy, P.E. - Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats, Diabetologia 9:489-491, 1973
  • Scharp, D.W., Kemp, C.B., Knight, M.J., Ballinger, W.F., Lacy, P.E. - The use of Ficoll in the preparation of viable islets of Langerhans from the rat pancreas, Transplantation 16:686-689, 1973
  • Kemp, C.B., Knight, M.J., Scharp, D.W., Lacy, P.E., Ballinger, W.F. - Transplantation of isolated pancreatic islets into the portal vein of diabetic rats, Nature 244:447, 1973
  • Kemp, C.B., Scharp, D.W., Knight, M.J., Ballinger, W.F., Lacy, P.E. - Importance of implantation site of pancreatic islet isografts in treatment of experimental diabetes, Surgical Forum 24:297-299, 1973
  • Knight, M.J., Scharp, D.W., Kemp, C.B., Ballinger, W.F., Lacy, P.E. - Effects of cold storage on the function of isolated pancreatic islets, Cryobiology, 10:89-90, 1973
  • Merrick, A.W., Scharp, D.W. - Electroencephalography of resting behavior in cattle, with observations on the question of sleep, Am. J. Vet. Res., 32:1893-1897, 1971
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