Scharp-Lacy is devoted to developing new treatments and therapies, including islet encapsulation and islet expansion, to improve the lives of all patients who suffer from this disease.
Published Articles
Scharp, D.W., Arulmoli, J., Morgan, K., Sunshine, H, Hao, E – “Advances in Human Islet Processing: Manufacturing Steps to Achieve Predictable Islet Outcomes from Research Pancreases, ABM Transplantation, 2019. 3(1):1-73.
Lee SH, Hao E, Scharp D, Levine F: Insulin Acts as a Repressive Factor to Inhibit the Ability of PAR2 to Induce Islet Cell Trans-differentiation. Islets. 2018:1-24.
Markmann, JF, Bartlett ST, Johnson P, Korsgren O, Hering BJ, Scharp,D … Executive Summary of IPITA-TTS Opinion Leaders Report on Future of B-Cell Replacement. Transplantation 100 (7), e25-e31, 2018.
Bartlett, ST, Markmann, JF, Johnson, JF, Korsgren, O, Hering, BJ, Scharp, DW... Report from IPITA-TTS opinion leaders meeting on the future of B-cell replacement, Transplantation 100 (Suppl 2), S1, 2016.
Tamaki, S., Nye, C., Slorach, E., Scharp, D., Blau, H.M., Whiteley, P., Pomerantz, J.H. – “Simultaneous silencing of multiple RB and p53 pathway members induces cell cycle reentry in intact human pancreatic islets.” BMC Biotechnology 14:86, 2014.
Scharp, DW, Marchetti, P. “Encapsulated Islets for Diabetes Therapy: History, Current Progress, and Critical Issues Requiring Solution” Advanced Drug Delivery Reviews, 67- 68: 35-73, August, 2014.
Kühtreiber, WM, Ho, LT, Kamireddy, A, Yacoub, JAW, Scharp, DW –Islet Isolation From Human Pancreas With Extended Cold Ischemia Time, Transplantation Proceedings 42: 2027- 2031, 2010.
Mirbolooki, MR, Taylor, GE, Knutzen, VK, Scharp, DW, Willcourt, R... Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications? Medical hypotheses 73 (3), 363-369, 2009.
Scharp, DW, Encapsulated human islet allografts: providing safety with efficacy, Cellular Transplantation, 135-153, 2007.
Coutts, M, Hinton, S, Zheng, J, Scharp, DW – Hypothermic storage and preservation of human pancreatic acinar tissue. In Vitro Cell Dev Biol 43:2-6, 2007.
Latta, P, Ricordi, C, Scharp, DW. Paul E Lacy, MD, PhD – February7, 1924 to February 15, 2005. Am J Transplantaion5 (5) 976-977
Scharp, D, Yu, X, Sheckler, V, Hubbell, J, Latta, P. – Clinically relevant results from encapsulated islet allografts implanted subcutaneously in diabetic baboons without long term immunosuppression. Diabetes 54: Sup 194-OR, 2005.
Cruise, G.M., Hegre, O.D., Lamberti, F.V., Hager, S.R., Hill, R., Scharp, D.W., Hubbell, J.A. - In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes, Cell Transplantation, 8:293-306, 1999
Cruise, G.M., Scharp, D.W., Hubbell, J.A. - Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels, Biomaterials 19:1287-1294, 1998
Cruise, G.M., Hegre, O.D., Scharp, D,W., Hubbell J.A., - A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylateupon porcine islets, Biotech. Bioeng. 57:655-665, 1998
Swanson, CJ, Olack, BJ, Flavin, KS, Mohanakumar, T, Brennan, DC ... Comparison of transplanted islets in patients with functioning versus non-functioning allografts, Transplantation proceedings 29 (4), 2241-2242,1997.
Olack, BJ, Swanson, CJ, Flavin, KS, Phelan, D, Brennan, DC, White, NH... Sensitization to HLA antigens in islet recipients with failing transplants, Transplantation proceedings 29 (4), 2268-2269, 1997
Brennan, DC, Flavin, KS, Scharp, DW, Lacy, PE, Olack, BJ, Swanson, C ... Long-term (>30 months) follow-up of a single successful kidney-islet transplant recipient, Transplantation proceedings 29 (4), 2231-2233, 1997.
Hill, R.S., Cruise, G.M., Hager, S.R., Lamberti, F.V., Yu, X., Garufis, C.L., Yu, Y., Mundwiler, K.E., Cole, J.F., Hubbell, J.A., Hegre, O.D., Scharp, D.W. - Immunoisolation of adult porcine islets for the treatment of diabetes mellitus, Annals of the NY Academy of Sciences 831:332-343, 1997
Shiroki R, Nazirrudin,D, Hoshinaga,K, Naide, Y, Scharp, DW. Human Peripheral blood lymphocyte-reconstituted, severe combined Immunodeficiency Mice as a model for porcine islet xenograft rejection in humans. Artificial Organs 20 (8) 878-882. 1996
Marchetti, P., Scharp, D.W., Finke, E.H., Swanson, C.J., Olack, B.J., Gerasimidi-Vazeou, A., Giannarelli, R., Navalesi, R., Lacy, P.E. - Prolonged survival of discordant porcine islet xenografts, Transplantation 61:1100-1102, 1996
Atkison, PR, Zucker, P, Hramiak, I, Paul, TL, Dupre, J, Behme, MT...Continued insulin dependence despite normal range insulin sensitivity and insulin connecting peptide levels in a kidney/islet transplant patient, Diabetes Care 19 (3), 236-240, 1996.
Davali GC, Scharp, DW, A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice, Transplantation 59 (6), 817-820, 1995.
Borge, MA, Scharp, DW, Picus, D, Percutaneous ablation of a pancreatic remnant with intraductal injection of neoprene, Journal of Vascular and Interventional Radiology 6 (5), 762-764, 1995.
P Marchetti, DW Scharp, M McLear, EH Finke, B Olack, C Swanson, ... , Insujlin inhibits its own secretion from isolated, perifused human pancreatic islets, Acta diabetologica 32 (2), 75-77, 1995.
Perdrizet, GA, Rewinski, MJ, Bartus, SA, Hull, D, Schweizer, RT, Scharp, DW, Albumin improves islet isolation: specific versus non-specific effects, Transplantation proceedings 27 (6), 3400-3402, 1995.
Marchetti, P., Scharp, D.W., Finke, E.H., Swanson, C.J., Olack, B.J., Gerasimidi-Vazeou, A., Giannarelli, R., Navalesi, R., Lacy, P.E. - Prolonged survival of discordant porcine islet xenografts, Transplantation 61:1100-1102, 1996
Atkison, PR, Zucker, P, Hramiak, I, Paul, TL, Dupre, J, Behme, MT...Continued insulin dependence despite normal range insulin sensitivity and insulin connecting peptide levels in a kidney/islet transplant patient, Diabetes Care 19 (3), 236-240, 1996.
Davali GC, Scharp, DW, A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice, Transplantation 59 (6), 817-820, 1995.
Borge, MA, Scharp, DW, Picus, D, Percutaneous ablation of a pancreatic remnant with intraductal injection of neoprene, Journal of Vascular and Interventional Radiology 6 (5), 762-764, 1995.
P Marchetti, DW Scharp, M McLear, EH Finke, B Olack, C Swanson, ... , Insujlin inhibits its own secretion from isolated, perifused human pancreatic islets, Acta diabetologica 32 (2), 75-77, 1995.
Shiroki, R, Mohanakumar, T, Scharp, DW, Analysis of the serological and cellular sensitization induced by encapsulated human islets transplantation in type 1 and the 2 diabetes patients, Cell transplantation 4 (5), 535-538, 1995
Perdrizet, GA, Rewinski, MJ, Bartus, SA, Hull, D, Schweizer, RT, Scharp, DW, Albumin improves islet isolation: specific versus non-specific effects, Transplantation proceedings 27 (6), 3400-3402, 1995.
Shiroki, R, Mohanakumar, T, Scharp, DW, Analysis of the serological and cellular sensitization induced by encapsulated human islets transplantation in type 1 and the 2 diabetes patients, Cell transplantation 4 (5), 535-538, 1995
Chern, H.T., Scharp, D.W. - Successful long-term cryopreservation of highly purified canine islets, European Surg Res 27:167-175, 1995
Brennan, D.C., Scharp, D.W., White, N.H., Flavin, K.S., Zukosky, J.M., Ansara, M.F., Cryer, P.E., Lacy, P.E. - Modification of methodology results in improvements in simultaneous kidney-islet success, Transplant Proc. 27(1):1349-1350, 1995
Ansara, M.F., Saudek, F., Newton, M., Cryer, P.E., Scharp, D.W. - Pancreatic islet transplantation prevents defective glucose counter-regulation in diabetic dogs, Transplant Proc. 26(2):664-665, 1994
Ansara, M.F., Saudek, F., Newton, M., Cryer, P.E., Scharp, D.W. - Pancreatic islet transplantation prevents defective glucose counter-regulation in diabetic dogs, Transplant Proc. 26(2):664-665, 1994
Scharp, DW, Gingerich, R, Giannarelli, RL Ansara, M, Olack, BJ ... Insulin and glucagon release from isolated, perifused human islets following low-temperature culture and cryopreservation, Transplantation proceedings 26 (2), 821-822, 1994.
Shiroki, R., Poindexter, N., Mohanakumar, T., Scharp, D.W. - Rejection of human islet allografts in human lymphocyte-reconstituted severe combined immunodeficient mice, Transplant Proc. 26(2):716-717, 1994
Barnett, D.W., Pressel, D.M., Chern, H.T., Scharp, D.W., Misler, S. - cAMP-Enhancing agents “permit” stimulus-secretion coupling in canine pancreatic islet ß-cells, J. Membrane Biol 138:113-120, 1994
Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Effect of different temporary immunosuppressive therapies and low-temperature culture on pancreatic islet xenograft survival (Pig-to-Mouse), Transplant Proc. 26(2):760-761, 1994
Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Effect of different temporary immunosuppressive therapies and low-temperature culture on pancreatic islet xenograft survival (Pig-to-Mouse), Transplant Proc. 26(2):760-761, 1994
Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Anti-CD4 antibody treatment in xenografts of differently immunomodulated porcine islets, Transplant Proc. 26(3):1132, 1994
Perdrizet, G.A., Rewinski, M.J., Schweizer, R.T., Scharp, D.W. - Heat shock and recovery protects pancreatic islets from warm ischemic injury, Transplant Proc. 26(6) 3477-3478, 1994
di Carlo, A., Scharp, D.W., Gingerich, R.L., Ansara, M.F., Olack, B.J., Swanson, C.J., Giannarelli, R., Navalesi, R. - C-peptide secretion from isolated perifused human islets: effect of culture and cryopreservation, Transplant Proc. 26(6) 3399, 1994
Marchetti, P., Scharp, D.W., Finke, E.H., Giannarelli, R., Swanson, C.J., Olack, B.J., Lacy, P.E., Navalesi, R. - Factors affecting in vitro and in vivo function of isolated porcine islets, Transplant Proc. 26(6):3419-3420, 1994
Scharp, D.W., Swanson, C.J., Olack, B.J., Latta, P.P., Hegre, O.D., Doherty, E.J., Gentile, F.T., Flavin, K.S., Ansara, M.F., Lacy, P.E. - Protection of encapsulated human islets implanted without immunosuppression in patients with Type I and Type II diabetes and in non-diabetic controls, Diabetes 43:1167, 1994
Shiroki, R, Poindexter, NJ, Mohanakumar, T, Scharp, DW, Rejection of human islet allografts in human lymphocyte-reconstituted severe combined immunodeficient mice, Transplantation proceedings 26 (2), 716-717, 1994.
Shiroki, R., Poindexter, N.J., Woodle, E.S., Hussain, M.S., Mohanakumar, T., Scharp, D.W. - Human peripheral blood lymphocyte reconstituted severe combined I mmunodeficient (hu-PBL-SCID) mice: a model for human islet allograft rejection, Transplantation 58:1555-1562, 1994
Marchetti, P., Scharp, D.W., McLear, M., Gingerich, R., Finke, E.H., Olack, B.J., Swanson, C.J., Giannarelli, R., Navalesi, R., Lacy, P.E. - Pulsatile insulin secretion from isolated human pancreatic islets, Diabetes 43:827-830, 1994
Marchetti, P., Kneteman, N.M., Swanson, C.J., Olack, B.J., Scharp, D.W. - Effect of cyclosporin treatment on metabolic and hormonal responses to mixed meal plus oral glucose in dogs with intrasplenic pancreatic islet autograft, Experimental Medicine
Marchetti, P, Scharp, DW, Pfifner, K Cryogenic storage of isolated, purified porcine pancreatic islets, Transplantation 57:340-346, 1994
Marchetti, P., Scharp, D.W., Pfiffner, K., Swanson, C.J., Finke, E.H., Olack, B.J., Gerasimidi-Vazeou, A., McLear, M., Lacy, P.E. - Cryogenic storage of isolated, purified porcine pancreatic islets, Transplantation 57:340-346, 1994
di Carlo, A., Scharp, D.W., Gingerich, R.L., Giannarelli, R., Ansara, M., Olack, B.J., Swanson, C.J., Navalesi, R. - Insulin and glucagon release from isolated, perifused human islets following low- temperature culture and cryopreservation, Transplant Proc. 26(2):821-822, 1994
Scharp, DW.Production of marked prolongation of Survival of Canine Islet Xenografts in Mice by anti-lymphocyte sera and L3T4 Antibody. Transplantation . 52(6) 1094-1096
Marchetti, P., Olack, B., Swanson, C., Newton, M., Scharp, D.W. - Assessment of longterm (1 year) graft survival and metabolic hormonal changes after intrasplenic canine pancreatic microfragment transplantation, Diabetes & Metabolism 19:17-24, 1993
Brelje, TC, Scharp, DW, Lacy, PE, Ogren, L, Talamantes, F, Robertson, M... Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets, Endocrinology 132 (2), 879-887,1993
Marchetti, P., Scharp, D.W., Olack, B.J., Swanson, C.J., Bier, D., Colelli, C., Toffolo, G., Newton, M., Navalesi, R. - Glucose metabolism, insulin sensitivity and glucagon secretion in dogs with intraportal or intrasplenic islet autografts, Transplant Proc 24(6):2828-2829, 1992
Marchetti, P., Pfiffner, K., Scharp, D.W., Lacy, P.E., Gerasimidi-Vazeou, A., Finke, E.H. - Successful cryopreservation of porcine pancreatic islets, Transplant Proc 24(3):1005- 1006, 1992
Porte, D, Baker, L, Bollinger, R, Genuth, S, Scharp, DW, Sutherland, DRW, Pancreas transplantation for patients with diabetes mellitus, Diabetes Care 15 (11), 1673, 1992
Marchetti, P., Finke, E.H., Swanson, C., Gerasimidi-Vazeou, A., Olack, B., Scharp, D.W., Navalesi, R., Lacy, P.E. - The potential of porcine islet xenotransplantation in the therapy of diabetes, Diab. Nutr. Metab. 5 (Suppl 1):151-154, 1992
Kneteman, N.M., Marchetti, P., Tordjman, K., Bier, D.M., Santiago, J.V., Swanson, C.J., Olack, B.J., Scharp, D.W. - Effect of cyclosporine on insulin secretion and insulin sensitivity in dogs with intrasplenic islet autotransplants, Surgery 111(4):430-437, 1992
Olack, B.J., Hill, A., Scharp, D.W., Lacy, P.E. - Automated purification of canine islets, Transplant Proc 24(3):1003-1004, 1992
Scharp, D.W., Marchetti, P., Swanson, C.J., Newton, M., McCullough, C.S., Olack, B.J. - The effect of transplantation site and islet mass on long-term survival and metabolic and hormonal function of canine purified islet autografts, Cell Transplantation 1:245- 254, 1992
McLear, M., Marchetti, P., Finke, E., Gerasimidi-Vazeou, A., Scharp, D.W., Lacy, P.E. - Porcine islet function: Effects of arginine, Leucine, and Butyrate, Transplant Proc 24(3):980-982, 1992
Marchetti, P., Swanson, C., McLear, M., Finke, E.H., Gerasimidi-Vazeou, A., Scharp, D.W., Lacy, P.E. - In vitro function and xenotransplantation of long-term (3 weeks) cultured porcine islets of Langerhans, Transplant Proc 24(2):637, 1992
Misler, S. Barnett, D.W., Pressel, D.M., Gillis, K.D., Scharp, D.W., Falke, L.C. - Stimulussecretion coupling in B cells of transplantable human islets of Langerhans: evidence for a critical role in Ca2+ entry. Diabetes 41 (6), 662-670, 1992
Marchetti, P., Scharp, D.W., Longwith, J.E., Swanson, C.J., Olack, B.J., GerasimidiVazeou, A., Finke, E.H., Lacy, P.E. - Prevention of contamination of isolated porcine islets of Langerhans, Transplantation 53(6):1364-1366, 1992
Scharp, D.W., Lacy, P.E., McLear, M., Longwith, J.E., Olack, B.J. - The bioburden of 590 consecutive human pancreata for islet transplant research, Transplant Proc 24(3):974- 975, 1992
Marchetti, P., Finke, E.H., Swanson, C., Gerasimidi-Vazeou, A., Olack, B., Scharp, D.W., Navalesi, R., Lacy, P.E. - The potential of porcine islet xenotransplantation in the therapy of diabetes, Diab. Nutr. Metab. 5 (Suppl 1):151-154, 1992
Falqui, L., Finke, E.H., Carel, J.C., Scharp, D.W., Lacy, P.E. - Marked prolongation of human islet xenograft survival (human to mouse) by low-temperature culture and temporary immunosuppression with human and mouse anti-lymphocyte sera, Transplantation 51:1322-1324, 1991
Marchetti, P., Finke, E.H., Gerasimidi-Vazeou, A., Falqui, L., Scharp, D.W., Lacy P.E.- Automated large scale isolation, in vitro function and xenotransplantation of porcine islets of Langerhans, Transplantation 52:209-213, 1991
Scharp, D.W., Lacy P.E. - The clinical feasibility of human islet transplantation, Clinical Diabetes 42- 45, May/June, 1991
Falqui, L., Finke, E.H., Carel, J.C., Scharp, D.W., Lacy, P.E. - Marked prolongation of human islet xenograft survival (human to mouse) by low-temperature culture and temporary immunosuppression with human and mouse anti-lymphocyte sera, Transplantation 51:1322-1324, 1991
Scharp, D.W., Lacy, P.E., Weide, L.G., Marchetti, P., McCullough, C.S., Flavin, K., Santiago, J.V. - Intraportal islet allografts: the use of a stimulation index to represent functional results, Transplant Proc 23(1):796-798, 1991
Finke, E., Marchetti, P., Falqui, L., Swanson, C., McLear, M., Olack, B., Scharp, D.W., Lacy, P.E. - Large scale isolation, function and transplantation of islets of Langerhans from the adult pig pancreas, Transplant Proc 23(1):772-773, 1991.
Lacy, PE, Scharp, DW, Prevention of rejection of islet allografts and xenografts without continuous immunosuppression of the recipients, Organ Transplantation 1990, 397- 404, 1991.
Scharp, D.W., Lacy, P.E., Santiago, J.V., McCullough, C.S., Weide, L.G., Boyle, P.J., Falqui, L., Marchetti, P., Ricordi, C., Gingerich, R.L., Jaffe, A.S., Cryer, P.E., Hanto, D.W., Anderson, C.B., Flye, M.W., - Results of our first nine intraportal islet allografts in Type 1, insulin-dependent diabetic patients, Transplantation 51:76-85, 1991
Atkinson, M.A., Holmes, L.H., Scharp, D.W., Lacy, P.E., Maclaren, N.K. - No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes, J Clin Invest 87:721-724, 1991
Kowalski, L., Falqui, L., Lacy, P.E., Scharp, D.W. - Production of marked prolongation of survival of canine islet xenografts in mice by antilymphocyte sera and L3T4 antibody, Transplantation 52:1094- 1097, 1991
Atkinson, M.A., Maclaren, N.K., Holmes, L., Scharp, D.W., Lacy, P.E., Riley, W.J. - The natural history and predictive value of Mr 64,000 autoantibodies for insulin-dependent diabetes mellitus, J Autoimmunity 3:41-45, 1990
Ricordi, C., Gray, D.W.R., Hering, B.J., et al - Islet isolation assessment in man and large animals, Acta Diabetoal. Lat. 27:185-195, 1990
Atkinson, M.A., Maclaren, N.K., Riley, W.J., Scharp, D.W., Lacy, P.E. – The Natural History and Predictive Value of 64,000 Mr autoantibodies as predictors of insulin dependent diabetes, Lancet 335:1357-1360, 1990
Kämpe, O, Velloso, L, Andersson, A, Karlsson, A, Atkinson, MA, Maclaren, NK, Scharp, DW ... No role of 65 kD heat-shock protein in diabetes. The Lancet 336 (8725), 1250- 1251, 1990.
Kneteman, NM, Cattral, MC, Warnock, GL, Scharp, DW, Jaspan, JL ... Immunosuppression and pancreatic islet transplantation, Hormone and metabolic research. Supplement series 25, 193-199, 1990.
Medoff, G., Sagal, S., Krogstad, D., Peters, M., Hogan, J., Scharp, D. - Clinical Pathology Conference - Abdominal pain, fever, and weight loss in a 61 year-old Arabian Man, Am J Medicine 89:83-90, 1990
Chern, H.T., Scharp, D.W. - Viability assessment of cryopreserved canine islets in vivo, Endocrine Surgery 7(3):355-360, 1990
Scharp, D.W., Olack, B.J., Swanson, C.J., Marchetti, P. - Normal reproductive function in dogs with islet autograft, Transplant Proc 22(5):2403-2404, 1990
Permutt, M.A., Koranyi, L., Keller, K., Lacy, P.E., Scharp, D.W., Mueckler, M. - Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA, Proc Natl Acad Sci USA 86:8688- 8692, 1989
Dotta, F., Colman, P.G., Nayak, R.C., Lombardi, D., Scharp, D.W., Andreani, D., Pontieri, G.M., di Mario, U., Lenti, L., Eisenbarth, G.S. - Ganglioside expression in human pancreatic islets, Diabetes 38:1478-1483, 1989
Callery, M.P., Ricordi, C., Scharp, D.W., Kamei, T., Swanson, C.J., Lacy, P.E., Flye, M.W. - Hepatic insufficiency following portacaval shunting is prevented by prior intraportal pancreatic islet autotransplantation. Surgery 106:257-266, 1989
Schmidt, R.E., Plurad, S.B., Olack, B.J., Scharp, D.W. - The effect of pancreatic islet t ransplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic Streptozotocin diabetic rats, Brian Research 497:393-398, 1989
Brelje, T.C., Scharp, D.W., Sorenson, R.L. - Three-dimensional imaging of intact, isolated islets of Langerhans using Confocal microscopy, Diabetes 38:808-814, 1989
Kneteman, N.M., Alderson, D., Scharp, D.W., Lacy, P.E. - Long-term cryogenic storage of purified adult human islets of Langerhans, Diabetes 38:386-396, 1989
Kneteman, N.M., Alderson, D., Scharp, D.W., Lacy, P.E. - Prolonged cyropreservation of purified human pancreatic islets, Diabetes 38:176-178, 1989
Ricordi, C., Lacy, P.E., Scharp, D.W. - Automated islet isolation from human pancreas, Diabetes 38 (Suppl. 1):140-142, 1989
Scharp, D.W., Lacy, P.E., Ricordi, C., Boyle, P., Santiago, J., Cryer, P., Gingerich, R., Jaffe, A., Anderson, C.B., Flye, M.W. - Human islet transplantation in patients with Type 1 diabetes, Transplant Proc 21 (No. 1):2744-2745, February 1989
Misler, S., Gee, W.M., Gillis, K.D., Scharp, D.W., Falke, L.C. - A metabolite-regulated ATPsensitive K+ channel in human pancreatic islet cells, Diabetes 38:422-427, 1989
Kneteman, NM, Alderson,D, Scharp, DW, Lacy, PE. Long-term mass storage of purified human pancreatic islets, Transplantation proceedings 20 (5), 1023-1025, 1988.
Ricordi, C., Kneteman, N.M., Scharp, D.W., Lacy, P.E. - Transplantation of cryopreserved human pancreatic islets into diabetic nude mice, World J. Surgery 12:861-865, 1988
Corlett, M.P., Scharp, D.W. - The effect of pancreatic warm ischemia on islet isolation in rats and dogs, J. Surg. Research, 45:531-536, 1988
Ricordi, C., Scharp, D.W., Lacy, P.E. - Mass isolation of human pancreatic islets for transplantation. Proceedings from XXVI World Congress of the International College of Surgeons, Milan, Italy, July 3- 9, 1988, Monduzzi Editore S.p.A.
Ricordi, C., Scharp, D.W., Lacy, P.E. - Reversal of diabetes in nude mice after transplantation of fresh and 7 day cultured (24°C) human pancreatic islets, Transplantation 45:994-996, 1988
Corlett, M.P., Scharp, D.W., Lacy, P.E. - Microbial contamination risks in human islet isolation, Transplant Proc 20 (Suppl. 1):894-895, 1988
Turk, J., Hughes, J.H., Easom, R.A., Wolf, B.A., Scharp, D.W., Lacy, P.E., McDaniel, M.L. - Arachidonic acid metabolism and insulin secretion by isolated human pancreatic islets, Diabetes 37:992-996, 1988
Ricordi, C., Lacy, P.E., Finke, E.H., Olack, B.J., Scharp, D.W. - Automated method for isolation of human pancreatic islets, Diabetes 37:413-420, 1988
Fonseca, P., Scharp, D.W. - Use of oxygen free radical scavengers to increase the yields of isolated rat islets after pancreatic warm ischemia, Surgical Forum 38:371-373, 1987
Kneteman, N.M., Alderson, D., Scharp, D.W. - Long-term normoglycemia in pancreatectomized dogs following pancreatic islet allotransplantation and cyclosporine immunosuppression, Transplantation 44(5):595-599, 1987
Scharp, D.W., Lacy, P.E., Finke, E., Olack, B.J. - Low-temperature culture of human islets isolated by the distention method and purified with Ficoll or Percoll gradients, Surgery 102:869-879, 1987
Greider, MH, Scharp, DW, Gingerich, RL, Enhanced preservation of endosecretory granules in PP-cells of the canine pancreas. Regulatory peptides 18 (5-6), 299-306, 1987.
Kneteman, N.M., Alderson, D., Scharp, D.W. - The isolation and purification of human pancreatic islets, Transplant Proc. 19(4):3469-3470, 1987
Alderson, D., Kneteman, N.M., Olack, B.J., Scharp, D.W. - Isolation and quantification of canine islet tissue for transplantation, Transplantation 43(4):579-581, 1987
Scharp, D.W., Alderson, D., Kneteman, N.M. - The effect of immunosuppression on islet transplant function in the dog, Transplant Proc. 19(1) 952-953, 1987
Hymer, W.C., Scharp, D.W., et al. - Continuous flow electrophoretic separation of proteins and cells from mammalian tissues, Cell Biophysics 10:61-85, 1987
Alderson, D., Kneteman, N.M., Scharp, D.W. - The isolation of purified human islets of Langerhans, Transplant Proc. 19(1):916-917, 1987
Kneteman, N.M., Alderson, D., Scharp, D.W. - Cyclosporine A immunosuppression of allotransplanted canine pancreatic islets, Transplant. Proc., 19(1):950-951, 1987
Scharp, D.W., Alderson, D., Kneteman, N.M. - Optimization of islet preparations for clinical transplantation. Transplant Proc. 18(6):1814-1816, 1986
Scharp, D.W., Lacy, P.E., Alderson, D., Kneteman, N.M. - The procurement and distribution of cadaver human pancreas for islet isolation and transplantation. The Use of Human Tissues and Organs for Research and Transplant: Proceedings of the Second I nternational Conference: National Diabetes Research Interchange April 1986:61-70
Downing, R., Morrissey, S., Kiske, D., Scharp, D.W. - Does the purity of intraportal islet isografts affect their endocrine function?, J. Surg. Research 41(1):41-46, 1986
Scharp, DW, Long, J, Feldmeier, M, Olack, B, O’Shaughnessy, Swansonm, C. Automated Methods of Mass Islet Isolation. Methods in Diabetes Research 1 (Part C), 225-236. 1985
Martin, K.W., Morian, J.P., Jr., Lee, J.K.T., Scharp, D.W. - Demonstration of splenic artery pseudoaneurysm by Magnetic Resonance Imaging, J. of Computer Assisted Tomography 9(1):190- 192, 1985
Heiken, J.P., Balfe, D.M., Picus, D., Scharp, D.W. - Radical pancreatectomy: Postoperative evaluation by CT, Radiology 153:211-215, 1984
Sparks, RE, Mason, NS, Scharp, DW, Some Present Directions in Research on Tissue Transplantation Chambers, Biomaterials in Artificial Organs, 193-199, 1984.
Scharp, D.W. - Clinical feasibility of islet transplantation, Transplant Proc. 16(3):820-825, 1984
Scharp, D.W., Mason, N.S., Sparks, R.E. - Islet immunoisolation: the use of hybrid artificial organs to prevent islet tissue rejection, World J. of Surgery 8:221-229, 1984
Scharp, DW, Transplantation of pancreatic islet cells – Introduction, World Journal of Surgery 8 (2), 135-136, 1984
Scharp, D.W. - Isolation and transplantation of islet tissue, World J. of Surgery 8:143- 151,1984
Giddings, S.J., Rotwein, P., Chirgwin, J.M., Scharp, D.W., Permutt, M.A. - Analysis of insulin gene expression in human pancreas, Diabetes 32:777-780, 1983
Schmidt, R.E., Santiago, B.P., Olack, B.J., Scharp, D.W. - The effect of pancreatic islet t ransplantation and insulin therapy on experimental diabetic autonomic neuropathy, Diabetes 32:532- 540, 1983
Sparks, RE, Mason, TC, Scharp, DW, A distributed source-model for the hybrid artificial pancreas, ASAIO Journal 29 (1), 460-462, 1983.
Long, J.A., Britt, L.D., Olack, B.J., Scharp, D.W. - Autotransplantation of isolated canine islets, Transplant Proc. 15:1332-1338, 1983
Scharp, D.W., Long, J.A. - Studies of islet isolation and transplantation, Cryobiology 20:129-137, 1983
Scharp, DW, Lacy, PE, The isolation and alteration of islet tissue for transplantation. In Vitro – Journal of the Tissue Culture Association. 18 (3), 316-317, 1982.
Britt, L.D., Scharp, D.W., Lacy, P.E., Slavin, S., Transplantation of islet cells across major histocompatibility barriers after total lymphoid irradiation and infusion of allogeneric bone marrow cells, Diabetes 31 Aupp 4), 63-68, 1982.
Gingerich, R.L., Scharp, D.W., Grieder, M.H., Dye, E.S., Mousel, K.A. - A new in vitro model for studies of pancreatic polypeptide secretion and biochemistry, Regulatory Peptides 5:13-25, 1982
Sparks, R.E., Mason, N.S., Finley, T.C., Scharp, D.W., Development, testing, and modeling of an islet transplantation chamber, ASAIO Journal 28 91), 229-231, 1982.
Yasunami, Y., Lacy, P.E., Scharp, D.W., Britt, L.D. - Isolation and transplantation of islet cells from the neonatal pig pancreas, Surgical Forum 33, 359-361, 1982
Greider, MH, Gingerich, RL, Scharp, DW, in vitro studies of canine pseudo-islets, Cellular Basis of Chemical Messengers in the Digestive System, 317-321, 1981
Paquette, T.L., Gingerich, R., Scharp, D.W. - Altered amidation of pancreatic polypeptide in culture, Biochemistry 20:7403-7408, 1981
Scharp, DW, Rejection of islet isografts in a strain of Lewis rats, Transplantation 31 (3) 229- 230, 1981.
Bergen, J., Mason, N.S., Scharp, D.W., Sparks, R.E. - Insulin inhibition of islets in transplantation chambers, Artificial Organs 5:787-791, 1981
Britt, L.D., Scharp, D.W., Lacy, P.E., Slavin, S. - Transplantation of islet cells across major histocompatibility barriers after total lymphoid irradiation and infusion of allogeneic bone marrow cells, Diabetes 31:36-38, 1982
Silberberg,R, Scharp, DW, LEsker, PA. Biochemical Studies of Long Bone from Diabetic Rats and Rats Bearing Transplanted Pancreatic Islets.,Pathobiology 49(2) 61-67.
Rajotte, R.V., Scharp, D.W., Downing, R., Preston, R., Molnar, G.D., Ballinger, W.F. - Pancreatic islet banking: the transplantation of frozen-thawed rat islets transported between Centers, Cryobiology 18:357-369, 1981
Silberberg, R., Scharp, D.W., Lesker, P.A. - Biochemical studies of bone from diabetic rats and rats bearing transplanted pancreatic islets, Experimental Cell Biology 49:61-67, 1981
RV Rajotte, DW Scharp, R Downing, P Preston, GD Molnar, WF Ballinger, Transplantation of frozen-thawed rat islets of Lanagerhans after sucrose versus step dilution, Cryobiology 17 (6), 618-619, 1981.
Grieder, M.H., Gingerich, R.L., Scharp, D.W. - In Vitro studies of canine pseudo-islets. UCLA Symposium - Cellular Basis of Chemical Messengers in the Digestive System”, Los Angeles, January 16-18, 1980
Downing, R., Scharp, D.W., Ballinger, W.F., An improved technique for the isolation and identification of mammalian islets of Langerhans, Transplantation 29(1), 79.82, 1980.
Feldman, S.D., Scharp, D.W., Lacy, P.E., Ballinger, W.F. - Fetal pancreas isografts, cultured and uncultured, to reverse streptozotocin induced diabetes mellitus, J. Surgical Research 29:309-318, 1980
Merrell, R.C., Scharp, D.W., Gingerich, R., Feldmeier, M.M., Grieder, M., Downing, R. - New approaches to the separation of islet cells, Surgical Forum 30:303-305, 1979
Downing, R., Scharp, D.W., Merrell, R.C., Grieder, M., Ballinger, W.F. - Venous versus ductal distension of the dog pancreas for isolation of islets, Surgical Forum 30:422-424, 1979
Scharp, D.W., Downing, R., Merrell, R.C., Grieder, M. - Isolating the elusive islet, Diabetes 29(1):19- 30, 1980
Downing, R., Scharp, D.W., Ballinger, W.F. - An improved technique for the isolation and identification of mammalian islets of Langerhans, Transplantation 29:79-83, 1980
Merrell, RC, Scharp, DW, Gingerich, R, Feldmeier, M, Greider, M, Downing, R. New Approaches to Separation of Islet Cells. Surgical Forum 30. 301-305, 1978.
Downing, R., Scharp, D.W., Merrell, R., Greideer, M., Ballinger, W.F. Venous versus ductal distension of the canine pancreas for isolation of islets, Surgical Forum 30:422-424, 1979.
Scharp,DW, Merrell, RC, Feldmeier, MM, Downing, R, Ballinger, WG.Pseudo-islet Formation and Culture from Canine Isolated Pancreatic Cells. InVitro Journal Tissue Culture Association 15(3) 216, 1979
Krupin, T., Waltman, S.R., Scharp, D.W., Oestrich, G., Feldman, S.D., Becker, D., Ballinger, W.F., Lacy, P.E. - Ocular fluorophotometry in experimental diabetes mellitus: The effect of pancreatic islet isografts, Investigative Ophthalmology & Visual Science 18:1185-190, 1979
Scharp, D, Krupin, T, Waltman, S, Oestrich, C, Feldman, S, Ballinger, W ... Relationship of abnormal insulin release to fluorophotometry in experimental diabetes, Diabetes 27, 435-435, 1978.
Scharp, D, Krupin, T, Waltman, S, Oestrich, C, Feldman, S, Ballinger, W ... Relationship of abnormal insulin release to fluorophotometry in experimental diabetes, Diabetes 27, 435-435, 1978.
Scharp, D.W., Merrell, R.C., Feldman, S.D., Downing, R., Lacy P,E., Ballinger, W. - The use of gyrotational culture for the preservation of isolated islets, Surgical Forum 29:100- 102, 1978
Feldman, S., Scharp, D., Hirshberg, G., Dodi, G., Ballinger, W., Lacy, P.E. - Streptozotocininduced liver tumors, Transplantation 24:152-154, 1977
Griffith, R.C., Scharp, D.W., Hartman, B.K., Ballinger, W.F., Lacy, P.E. - A morphologic study of intrahepatic portal vein islet isografts, Diabetes 26:201-214, 1977
Scharp, DW, Merrell, RC, Feldman SD, Ruwe, EA, Feldmeier, M. Long-Term Culture of Islets of Langerhans Utilizing a Rotational Culture Method. In Vitro- Journal of Tissue Culture Association.13 (3), 174.
Karl, R.C., Scharp, D.W., Ballinger, W.F., Lacy, P.E. - Transplantation of insulin-secreting tissues, J British Society Gastroenterology - GUT 18:1062-1072, 1977
Feldman, S., Hirshberg, G., Dodi, G., Raizman, M., Scharp, D., Ballinger, W., Lacy, P.E. - Intrasplenic islet isografts, Surgery 82:386-394, 1977
Scharp, D.W., Murphy, J.J., Newton, W.T., Ballinger, W.F., Lacy, P.E. - Application of an improved isolation technique for islet transplantation in primates and rats, Transplant. Proc. 6(1):739-741, 1975
Scharp, D.W., Murphy, J.J., Newton, W.T., Ballinger, W.F., Lacy, P.E. - Transplantation of islets of Langerhans in diabetic Rhesus monkeys, Surgery 77:100-105, 1975
MJ Knight, DW Scharp, CB Kemp, SB Nunnelly, Ballinger WF, PE Lacy, Cryopreservation of pancreatic islets. European Surgical Research, 6, 89-89, 1974.
DW Scharp, CB Kemp, MJ Knight, JJ Murphy, WT Newton, WF Ballinger, ... Long-term results of portal vein islet isografts and allografts in treatment of streptozotocin-induced diabetes, Diabetes 23, 359-359, 1974.
Ballinger, WF, Lacy, PE, Scharp. DW, Kemp, CB, Knight, M- Isografts and Allografts of Pancreatic Islets in Rats. British J Surgery, 60(4): 313, 1973
Ballinger, WF, Lacy, PE, Scharp. DW, Kemp, CB, Knight, M- Isografts and Allografts of Pancreatic Islets in Rats. British J Surgery, 60(4): 313, 1973
Kemp, C.B., Knight, M.J., Scharp, D.W., Ballinger, W.F., Lacy, P.E. - Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats, Diabetologia 9:489-491, 1973
Scharp, D.W., Kemp, C.B., Knight, M.J., Ballinger, W.F., Lacy, P.E. - The use of Ficoll in the preparation of viable islets of Langerhans from the rat pancreas, Transplantation 16:686-689, 1973
Kemp, C.B., Knight, M.J., Scharp, D.W., Lacy, P.E., Ballinger, W.F. - Transplantation of isolated pancreatic islets into the portal vein of diabetic rats, Nature 244:447, 1973
Kemp, C.B., Scharp, D.W., Knight, M.J., Ballinger, W.F., Lacy, P.E. - Importance of implantation site of pancreatic islet isografts in treatment of experimental diabetes, Surgical Forum 24:297-299, 1973
Knight, M.J., Scharp, D.W., Kemp, C.B., Ballinger, W.F., Lacy, P.E. - Effects of cold storage on the function of isolated pancreatic islets, Cryobiology, 10:89-90, 1973
Merrick, A.W., Scharp, D.W. - Electroencephalography of resting behavior in cattle, with observations on the question of sleep, Am. J. Vet. Res., 32:1893-1897, 1971