Diabetes

Type 1 and Type 2 Research 

FINDING SOLUTIONS

Research Focus

Scharp-Lacy is devoted to developing new treatments and therapies, including islet encapsulation and islet expansion, to improve the lives of all patients who suffer from this disease.

DIABETES RESEARCH

Latest News & Articles

Published Articles

  • Scharp, D.W., Arulmoli, J., Morgan, K., Sunshine, H, Hao, E – “Advances in Human Islet Processing: Manufacturing Steps to Achieve Predictable Islet Outcomes from Research Pancreases, ABM Transplantation, 2019. 3(1):1-73.
  • Lee SH, Hao E, Scharp D, Levine F: Insulin Acts as a Repressive Factor to Inhibit the Ability of PAR2 to Induce Islet Cell Trans-differentiation. Islets. 2018:1-24.
  • Markmann, JF, Bartlett ST, Johnson P, Korsgren O, Hering BJ, Scharp,D … Executive Summary of IPITA-TTS Opinion Leaders Report on Future of B-Cell Replacement. Transplantation 100 (7), e25-e31, 2018.
  • Bartlett, ST, Markmann, JF, Johnson, JF, Korsgren, O, Hering, BJ, Scharp, DW... Report from IPITA-TTS opinion leaders meeting on the future of B-cell replacement, Transplantation 100 (Suppl 2), S1, 2016.
  • Tamaki, S., Nye, C., Slorach, E., Scharp, D., Blau, H.M., Whiteley, P., Pomerantz, J.H. – “Simultaneous silencing of multiple RB and p53 pathway members induces cell cycle reentry in intact human pancreatic islets.” BMC Biotechnology 14:86, 2014.
  • Scharp, DW, Marchetti, P. “Encapsulated Islets for Diabetes Therapy: History, Current Progress, and Critical Issues Requiring Solution” Advanced Drug Delivery Reviews, 67- 68: 35-73, August, 2014.
  • Kühtreiber, WM, Ho, LT, Kamireddy, A, Yacoub, JAW, Scharp, DW –Islet Isolation From Human Pancreas With Extended Cold Ischemia Time, Transplantation Proceedings 42: 2027- 2031, 2010.
  • Mirbolooki, MR, Taylor, GE, Knutzen, VK, Scharp, DW, Willcourt, R... Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications? Medical hypotheses 73 (3), 363-369, 2009.
  • Scharp, DW, Encapsulated human islet allografts: providing safety with efficacy, Cellular Transplantation, 135-153, 2007.
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  • Coutts, M, Hinton, S, Zheng, J, Scharp, DW – Hypothermic storage and preservation of human pancreatic acinar tissue. In Vitro Cell Dev Biol 43:2-6, 2007.
  • Latta, P, Ricordi, C, Scharp, DW. Paul E Lacy, MD, PhD – February7, 1924 to February 15, 2005. Am J Transplantaion5 (5) 976-977
  • Scharp, D, Yu, X, Sheckler, V, Hubbell, J, Latta, P. – Clinically relevant results from encapsulated islet allografts implanted subcutaneously in diabetic baboons without long term immunosuppression. Diabetes 54: Sup 194-OR, 2005.
  • Cruise, G.M., Hegre, O.D., Lamberti, F.V., Hager, S.R., Hill, R., Scharp, D.W., Hubbell, J.A. - In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes, Cell Transplantation, 8:293-306, 1999
  • Cruise, G.M., Scharp, D.W., Hubbell, J.A. - Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels, Biomaterials 19:1287-1294, 1998
  • Cruise, G.M., Hegre, O.D., Scharp, D,W., Hubbell J.A., - A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylateupon porcine islets, Biotech. Bioeng. 57:655-665, 1998
  • Swanson, CJ, Olack, BJ, Flavin, KS, Mohanakumar, T, Brennan, DC ... Comparison of transplanted islets in patients with functioning versus non-functioning allografts, Transplantation proceedings 29 (4), 2241-2242,1997.
  • Olack, BJ, Swanson, CJ, Flavin, KS, Phelan, D, Brennan, DC, White, NH... Sensitization to HLA antigens in islet recipients with failing transplants, Transplantation proceedings 29 (4), 2268-2269, 1997
  • Brennan, DC, Flavin, KS, Scharp, DW, Lacy, PE, Olack, BJ, Swanson, C ... Long-term (>30 months) follow-up of a single successful kidney-islet transplant recipient, Transplantation proceedings 29 (4), 2231-2233, 1997.
  • Hill, R.S., Cruise, G.M., Hager, S.R., Lamberti, F.V., Yu, X., Garufis, C.L., Yu, Y., Mundwiler, K.E., Cole, J.F., Hubbell, J.A., Hegre, O.D., Scharp, D.W. - Immunoisolation of adult porcine islets for the treatment of diabetes mellitus, Annals of the NY Academy of Sciences 831:332-343, 1997
  • Shiroki R, Nazirrudin,D, Hoshinaga,K, Naide, Y, Scharp, DW. Human Peripheral blood lymphocyte-reconstituted, severe combined Immunodeficiency Mice as a model for porcine islet xenograft rejection in humans. Artificial Organs 20 (8) 878-882. 1996
  • Marchetti, P., Scharp, D.W., Finke, E.H., Swanson, C.J., Olack, B.J., Gerasimidi-Vazeou, A., Giannarelli, R., Navalesi, R., Lacy, P.E. - Prolonged survival of discordant porcine islet xenografts, Transplantation 61:1100-1102, 1996
  • Atkison, PR, Zucker, P, Hramiak, I, Paul, TL, Dupre, J, Behme, MT...Continued insulin dependence despite normal range insulin sensitivity and insulin connecting peptide levels in a kidney/islet transplant patient, Diabetes Care 19 (3), 236-240, 1996.
  • Marchetti, P, Scharp, DW, Giannarelli, R, Benzi, L, Cicchetti, P, Ciccarone, A... Metformin potentiates glucose-stimulated insulin secretion, Diabetes Care 19, 781-782, 1996.
  • Davali GC, Scharp, DW, A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice, Transplantation 59 (6), 817-820, 1995.
  • Borge, MA, Scharp, DW, Picus, D, Percutaneous ablation of a pancreatic remnant with intraductal injection of neoprene, Journal of Vascular and Interventional Radiology 6 (5), 762-764, 1995.
  • P Marchetti, DW Scharp, M McLear, EH Finke, B Olack, C Swanson, ... , Insujlin inhibits its own secretion from isolated, perifused human pancreatic islets, Acta diabetologica 32 (2), 75-77, 1995.
  • Perdrizet, GA, Rewinski, MJ, Bartus, SA, Hull, D, Schweizer, RT, Scharp, DW, Albumin improves islet isolation: specific versus non-specific effects, Transplantation proceedings 27 (6), 3400-3402, 1995.
  • Marchetti, P., Scharp, D.W., Finke, E.H., Swanson, C.J., Olack, B.J., Gerasimidi-Vazeou, A., Giannarelli, R., Navalesi, R., Lacy, P.E. - Prolonged survival of discordant porcine islet xenografts, Transplantation 61:1100-1102, 1996
  • Atkison, PR, Zucker, P, Hramiak, I, Paul, TL, Dupre, J, Behme, MT...Continued insulin dependence despite normal range insulin sensitivity and insulin connecting peptide levels in a kidney/islet transplant patient, Diabetes Care 19 (3), 236-240, 1996.
  • Marchetti, P, Scharp, DW, Giannarelli, R, Benzi, L, Cicchetti, P, Ciccarone, A... Metformin potentiates glucose-stimulated insulin secretion, Diabetes Care 19, 781-782, 1996.
  • Davali GC, Scharp, DW, A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice, Transplantation 59 (6), 817-820, 1995.
  • Borge, MA, Scharp, DW, Picus, D, Percutaneous ablation of a pancreatic remnant with intraductal injection of neoprene, Journal of Vascular and Interventional Radiology 6 (5), 762-764, 1995.
  • P Marchetti, DW Scharp, M McLear, EH Finke, B Olack, C Swanson, ... , Insujlin inhibits its own secretion from isolated, perifused human pancreatic islets, Acta diabetologica 32 (2), 75-77, 1995.
  • Shiroki, R, Mohanakumar, T, Scharp, DW, Analysis of the serological and cellular sensitization induced by encapsulated human islets transplantation in type 1 and the 2 diabetes patients, Cell transplantation 4 (5), 535-538, 1995
  • Perdrizet, GA, Rewinski, MJ, Bartus, SA, Hull, D, Schweizer, RT, Scharp, DW, Albumin improves islet isolation: specific versus non-specific effects, Transplantation proceedings 27 (6), 3400-3402, 1995.
  • Shiroki, R, Mohanakumar, T, Scharp, DW, Analysis of the serological and cellular sensitization induced by encapsulated human islets transplantation in type 1 and the 2 diabetes patients, Cell transplantation 4 (5), 535-538, 1995
  • Chern, H.T., Scharp, D.W. - Successful long-term cryopreservation of highly purified canine islets, European Surg Res 27:167-175, 1995
  • Brennan, D.C., Scharp, D.W., White, N.H., Flavin, K.S., Zukosky, J.M., Ansara, M.F., Cryer, P.E., Lacy, P.E. - Modification of methodology results in improvements in simultaneous kidney-islet success, Transplant Proc. 27(1):1349-1350, 1995
  • Marchetti, P, Scharp, DW, Lacy, PE, Navalesi, R, Long-term survival of pig-to-mouse islet xenografts, Xenotransplantation 2 (3), 154-156, 1995.
  • Ansara, M.F., Saudek, F., Newton, M., Cryer, P.E., Scharp, D.W. - Pancreatic islet transplantation prevents defective glucose counter-regulation in diabetic dogs, Transplant Proc. 26(2):664-665, 1994
  • Ansara, M.F., Saudek, F., Newton, M., Cryer, P.E., Scharp, D.W. - Pancreatic islet transplantation prevents defective glucose counter-regulation in diabetic dogs, Transplant Proc. 26(2):664-665, 1994
  • Scharp, DW, Gingerich, R, Giannarelli, RL Ansara, M, Olack, BJ ... Insulin and glucagon release from isolated, perifused human islets following low-temperature culture and cryopreservation, Transplantation proceedings 26 (2), 821-822, 1994.
  • Shiroki, R., Poindexter, N., Mohanakumar, T., Scharp, D.W. - Rejection of human islet allografts in human lymphocyte-reconstituted severe combined immunodeficient mice, Transplant Proc. 26(2):716-717, 1994
  • Barnett, D.W., Pressel, D.M., Chern, H.T., Scharp, D.W., Misler, S. - cAMP-Enhancing agents “permit” stimulus-secretion coupling in canine pancreatic islet ß-cells, J. Membrane Biol 138:113-120, 1994
  • Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Effect of different temporary immunosuppressive therapies and low-temperature culture on pancreatic islet xenograft survival (Pig-to-Mouse), Transplant Proc. 26(2):760-761, 1994
  • Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Effect of different temporary immunosuppressive therapies and low-temperature culture on pancreatic islet xenograft survival (Pig-to-Mouse), Transplant Proc. 26(2):760-761, 1994
  • Marchetti, P., Scharp, D.W., Finke, E., Swanson, C.J., Gerasimidi-Vazeou, A., Olack, B.J., Navalesi, R., Lacy, P.E. - Anti-CD4 antibody treatment in xenografts of differently immunomodulated porcine islets, Transplant Proc. 26(3):1132, 1994
  • Perdrizet, G.A., Rewinski, M.J., Schweizer, R.T., Scharp, D.W. - Heat shock and recovery protects pancreatic islets from warm ischemic injury, Transplant Proc. 26(6) 3477-3478, 1994
  • di Carlo, A., Scharp, D.W., Gingerich, R.L., Ansara, M.F., Olack, B.J., Swanson, C.J., Giannarelli, R., Navalesi, R. - C-peptide secretion from isolated perifused human islets: effect of culture and cryopreservation, Transplant Proc. 26(6) 3399, 1994
  • Marchetti, P., Scharp, D.W., Finke, E.H., Giannarelli, R., Swanson, C.J., Olack, B.J., Lacy, P.E., Navalesi, R. - Factors affecting in vitro and in vivo function of isolated porcine islets, Transplant Proc. 26(6):3419-3420, 1994
  • Scharp, D.W., Swanson, C.J., Olack, B.J., Latta, P.P., Hegre, O.D., Doherty, E.J., Gentile, F.T., Flavin, K.S., Ansara, M.F., Lacy, P.E. - Protection of encapsulated human islets implanted without immunosuppression in patients with Type I and Type II diabetes and in non-diabetic controls, Diabetes 43:1167, 1994
  • Shiroki, R, Poindexter, NJ, Mohanakumar, T, Scharp, DW, Rejection of human islet allografts in human lymphocyte-reconstituted severe combined immunodeficient mice, Transplantation proceedings 26 (2), 716-717, 1994.
  • Shiroki, R., Poindexter, N.J., Woodle, E.S., Hussain, M.S., Mohanakumar, T., Scharp, D.W. - Human peripheral blood lymphocyte reconstituted severe combined I mmunodeficient (hu-PBL-SCID) mice: a model for human islet allograft rejection, Transplantation 58:1555-1562, 1994
  • Marchetti, P., Scharp, D.W., McLear, M., Gingerich, R., Finke, E.H., Olack, B.J., Swanson, C.J., Giannarelli, R., Navalesi, R., Lacy, P.E. - Pulsatile insulin secretion from isolated human pancreatic islets, Diabetes 43:827-830, 1994
  • Marchetti, P., Kneteman, N.M., Swanson, C.J., Olack, B.J., Scharp, D.W. - Effect of cyclosporin treatment on metabolic and hormonal responses to mixed meal plus oral glucose in dogs with intrasplenic pancreatic islet autograft, Experimental Medicine
  • Marchetti, P, Scharp, DW, Pfifner, K Cryogenic storage of isolated, purified porcine pancreatic islets, Transplantation 57:340-346, 1994
  • Marchetti, P., Scharp, D.W., Pfiffner, K., Swanson, C.J., Finke, E.H., Olack, B.J., Gerasimidi-Vazeou, A., McLear, M., Lacy, P.E. - Cryogenic storage of isolated, purified porcine pancreatic islets, Transplantation 57:340-346, 1994
  • di Carlo, A., Scharp, D.W., Gingerich, R.L., Giannarelli, R., Ansara, M., Olack, B.J., Swanson, C.J., Navalesi, R. - Insulin and glucagon release from isolated, perifused human islets following low- temperature culture and cryopreservation, Transplant Proc. 26(2):821-822, 1994
  • Scharp, DW.Production of marked prolongation of Survival of Canine Islet Xenografts in Mice by anti-lymphocyte sera and L3T4 Antibody. Transplantation . 52(6) 1094-1096
  • Marchetti, P., Olack, B., Swanson, C., Newton, M., Scharp, D.W. - Assessment of longterm (1 year) graft survival and metabolic hormonal changes after intrasplenic canine pancreatic microfragment transplantation, Diabetes & Metabolism 19:17-24, 1993
  • Brelje, TC, Scharp, DW, Lacy, PE, Ogren, L, Talamantes, F, Robertson, M... Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets, Endocrinology 132 (2), 879-887,1993
  • Marchetti, P., Scharp, D.W., Olack, B.J., Swanson, C.J., Bier, D., Colelli, C., Toffolo, G., Newton, M., Navalesi, R. - Glucose metabolism, insulin sensitivity and glucagon secretion in dogs with intraportal or intrasplenic islet autografts, Transplant Proc 24(6):2828-2829, 1992
  • Marchetti, P., Pfiffner, K., Scharp, D.W., Lacy, P.E., Gerasimidi-Vazeou, A., Finke, E.H. - Successful cryopreservation of porcine pancreatic islets, Transplant Proc 24(3):1005- 1006, 1992
  • Porte, D, Baker, L, Bollinger, R, Genuth, S, Scharp, DW, Sutherland, DRW, Pancreas transplantation for patients with diabetes mellitus, Diabetes Care 15 (11), 1673, 1992
  • Marchetti, P., Finke, E.H., Swanson, C., Gerasimidi-Vazeou, A., Olack, B., Scharp, D.W., Navalesi, R., Lacy, P.E. - The potential of porcine islet xenotransplantation in the therapy of diabetes, Diab. Nutr. Metab. 5 (Suppl 1):151-154, 1992
  • Kneteman, N.M., Marchetti, P., Tordjman, K., Bier, D.M., Santiago, J.V., Swanson, C.J., Olack, B.J., Scharp, D.W. - Effect of cyclosporine on insulin secretion and insulin sensitivity in dogs with intrasplenic islet autotransplants, Surgery 111(4):430-437, 1992
  • Olack, B.J., Hill, A., Scharp, D.W., Lacy, P.E. - Automated purification of canine islets, Transplant Proc 24(3):1003-1004, 1992
  • Scharp, D.W., Marchetti, P., Swanson, C.J., Newton, M., McCullough, C.S., Olack, B.J. - The effect of transplantation site and islet mass on long-term survival and metabolic and hormonal function of canine purified islet autografts, Cell Transplantation 1:245- 254, 1992
  • McLear, M., Marchetti, P., Finke, E., Gerasimidi-Vazeou, A., Scharp, D.W., Lacy, P.E. - Porcine islet function: Effects of arginine, Leucine, and Butyrate, Transplant Proc 24(3):980-982, 1992
  • Marchetti, P., Swanson, C., McLear, M., Finke, E.H., Gerasimidi-Vazeou, A., Scharp, D.W., Lacy, P.E. - In vitro function and xenotransplantation of long-term (3 weeks) cultured porcine islets of Langerhans, Transplant Proc 24(2):637, 1992
  • Misler, S. Barnett, D.W., Pressel, D.M., Gillis, K.D., Scharp, D.W., Falke, L.C. - Stimulussecretion coupling in B cells of transplantable human islets of Langerhans: evidence for a critical role in Ca2+ entry. Diabetes 41 (6), 662-670, 1992
  • Marchetti, P., Scharp, D.W., Longwith, J.E., Swanson, C.J., Olack, B.J., GerasimidiVazeou, A., Finke, E.H., Lacy, P.E. - Prevention of contamination of isolated porcine islets of Langerhans, Transplantation 53(6):1364-1366, 1992
  • Scharp, D.W., Lacy, P.E., McLear, M., Longwith, J.E., Olack, B.J. - The bioburden of 590 consecutive human pancreata for islet transplant research, Transplant Proc 24(3):974- 975, 1992
  • Marchetti, P., Finke, E.H., Swanson, C., Gerasimidi-Vazeou, A., Olack, B., Scharp, D.W., Navalesi, R., Lacy, P.E. - The potential of porcine islet xenotransplantation in the therapy of diabetes, Diab. Nutr. Metab. 5 (Suppl 1):151-154, 1992
  • Olack, B., Swanson, C., McLear, M., Longwith, J., Scharp, D.W., Lacy, P.E. - Islet purification using Euroficoll gradients, Transplant Proc 23(1):774-776, 1991
  • Falqui, L., Finke, E.H., Carel, J.C., Scharp, D.W., Lacy, P.E. - Marked prolongation of human islet xenograft survival (human to mouse) by low-temperature culture and temporary immunosuppression with human and mouse anti-lymphocyte sera, Transplantation 51:1322-1324, 1991
  • Marchetti, P., Finke, E.H., Gerasimidi-Vazeou, A., Falqui, L., Scharp, D.W., Lacy P.E.- Automated large scale isolation, in vitro function and xenotransplantation of porcine islets of Langerhans, Transplantation 52:209-213, 1991
  • Scharp, D.W., Lacy P.E. - The clinical feasibility of human islet transplantation, Clinical Diabetes 42- 45, May/June, 1991
  • Falqui, L., Finke, E.H., Carel, J.C., Scharp, D.W., Lacy, P.E. - Marked prolongation of human islet xenograft survival (human to mouse) by low-temperature culture and temporary immunosuppression with human and mouse anti-lymphocyte sera, Transplantation 51:1322-1324, 1991
  • Scharp, D.W., Lacy, P.E., Weide, L.G., Marchetti, P., McCullough, C.S., Flavin, K., Santiago, J.V. - Intraportal islet allografts: the use of a stimulation index to represent functional results, Transplant Proc 23(1):796-798, 1991
  • Finke, E., Marchetti, P., Falqui, L., Swanson, C., McLear, M., Olack, B., Scharp, D.W., Lacy, P.E. - Large scale isolation, function and transplantation of islets of Langerhans from the adult pig pancreas, Transplant Proc 23(1):772-773, 1991.
  • Lacy, PE, Scharp, DW, Prevention of rejection of islet allografts and xenografts without continuous immunosuppression of the recipients, Organ Transplantation 1990, 397- 404, 1991.
  • Scharp, D.W., Lacy, P.E., Santiago, J.V., McCullough, C.S., Weide, L.G., Boyle, P.J., Falqui, L., Marchetti, P., Ricordi, C., Gingerich, R.L., Jaffe, A.S., Cryer, P.E., Hanto, D.W., Anderson, C.B., Flye, M.W., - Results of our first nine intraportal islet allografts in Type 1, insulin-dependent diabetic patients, Transplantation 51:76-85, 1991
  • Atkinson, M.A., Holmes, L.H., Scharp, D.W., Lacy, P.E., Maclaren, N.K. - No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes, J Clin Invest 87:721-724, 1991
  • Kowalski, L., Falqui, L., Lacy, P.E., Scharp, D.W. - Production of marked prolongation of survival of canine islet xenografts in mice by antilymphocyte sera and L3T4 antibody, Transplantation 52:1094- 1097, 1991
  • Atkinson, M.A., Maclaren, N.K., Holmes, L., Scharp, D.W., Lacy, P.E., Riley, W.J. - The natural history and predictive value of Mr 64,000 autoantibodies for insulin-dependent diabetes mellitus, J Autoimmunity 3:41-45, 1990
  • Ricordi, C., Gray, D.W.R., Hering, B.J., et al - Islet isolation assessment in man and large animals, Acta Diabetoal. Lat. 27:185-195, 1990
  • Atkinson, M.A., Maclaren, N.K., Riley, W.J., Scharp, D.W., Lacy, P.E. – The Natural History and Predictive Value of 64,000 Mr autoantibodies as predictors of insulin dependent diabetes, Lancet 335:1357-1360, 1990
  • Kämpe, O, Velloso, L, Andersson, A, Karlsson, A, Atkinson, MA, Maclaren, NK, Scharp, DW ... No role of 65 kD heat-shock protein in diabetes. The Lancet 336 (8725), 1250- 1251, 1990.
  • Scharp, D.W., Lacy, P.E., Santiago, J.V., McCullough, C.S., Weide, L.G., Falqui, L., Marchetti, P., Gingerich, R.L., Jaffe, A.S., Cryer, P.E., Anderson, C.B., Flye, M.W. - Insulin independence after islet transplantation into Type 1 diabetic patient, Diabetes 39:515-518, 1990
  • Callery, M.P., Kamei, T., Flye, M.W., Davis, C.G., Swanson, C.J., Olack, B.J., Lacy, P.E., Scharp, D.W. - Intrahepatic islet autografts in dogs function despite completely diverting portacaval shunt, Transplant Proc 22:767-770, 1990
  • Kneteman, NM, Cattral, MC, Warnock, GL, Scharp, DW, Jaspan, JL ... Immunosuppression and pancreatic islet transplantation, Hormone and metabolic research. Supplement series 25, 193-199, 1990.
  • Medoff, G., Sagal, S., Krogstad, D., Peters, M., Hogan, J., Scharp, D. - Clinical Pathology Conference - Abdominal pain, fever, and weight loss in a 61 year-old Arabian Man, Am J Medicine 89:83-90, 1990
  • Chern, H.T., Scharp, D.W. - Viability assessment of cryopreserved canine islets in vivo, Endocrine Surgery 7(3):355-360, 1990
  • Scharp, D.W., Olack, B.J., Swanson, C.J., Marchetti, P. - Normal reproductive function in dogs with islet autograft, Transplant Proc 22(5):2403-2404, 1990
  • Permutt, M.A., Koranyi, L., Keller, K., Lacy, P.E., Scharp, D.W., Mueckler, M. - Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA, Proc Natl Acad Sci USA 86:8688- 8692, 1989
  • Dotta, F., Colman, P.G., Nayak, R.C., Lombardi, D., Scharp, D.W., Andreani, D., Pontieri, G.M., di Mario, U., Lenti, L., Eisenbarth, G.S. - Ganglioside expression in human pancreatic islets, Diabetes 38:1478-1483, 1989
  • Callery, M.P., Ricordi, C., Scharp, D.W., Kamei, T., Swanson, C.J., Lacy, P.E., Flye, M.W. - Hepatic insufficiency following portacaval shunting is prevented by prior intraportal pancreatic islet autotransplantation. Surgery 106:257-266, 1989
  • Schmidt, R.E., Plurad, S.B., Olack, B.J., Scharp, D.W. - The effect of pancreatic islet t ransplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic Streptozotocin diabetic rats, Brian Research 497:393-398, 1989
  • Brelje, T.C., Scharp, D.W., Sorenson, R.L. - Three-dimensional imaging of intact, isolated islets of Langerhans using Confocal microscopy, Diabetes 38:808-814, 1989
  • Kneteman, N.M., Alderson, D., Scharp, D.W., Lacy, P.E. - Long-term cryogenic storage of purified adult human islets of Langerhans, Diabetes 38:386-396, 1989
  • Kneteman, N.M., Alderson, D., Scharp, D.W., Lacy, P.E. - Prolonged cyropreservation of purified human pancreatic islets, Diabetes 38:176-178, 1989
  • Ricordi, C., Lacy, P.E., Scharp, D.W. - Automated islet isolation from human pancreas, Diabetes 38 (Suppl. 1):140-142, 1989
  • Scharp, D.W. - Islet Transplantation, Diabetes 38: (Suppl. 1):323-325, 1989
  • Scharp, D.W., Lacy, P.E., Ricordi, C., Boyle, P., Santiago, J., Cryer, P., Gingerich, R., Jaffe, A., Anderson, C.B., Flye, M.W. - Human islet transplantation in patients with Type 1 diabetes, Transplant Proc 21 (No. 1):2744-2745, February 1989
  • Misler, S., Gee, W.M., Gillis, K.D., Scharp, D.W., Falke, L.C. - A metabolite-regulated ATPsensitive K+ channel in human pancreatic islet cells, Diabetes 38:422-427, 1989
  • Kneteman, NM, Alderson,D, Scharp, DW, Lacy, PE. Long-term mass storage of purified human pancreatic islets, Transplantation proceedings 20 (5), 1023-1025, 1988.
  • Ricordi, C., Kneteman, N.M., Scharp, D.W., Lacy, P.E. - Transplantation of cryopreserved human pancreatic islets into diabetic nude mice, World J. Surgery 12:861-865, 1988
  • Corlett, M.P., Scharp, D.W. - The effect of pancreatic warm ischemia on islet isolation in rats and dogs, J. Surg. Research, 45:531-536, 1988
  • Ricordi, C., Scharp, D.W., Lacy, P.E. - Mass isolation of human pancreatic islets for transplantation. Proceedings from XXVI World Congress of the International College of Surgeons, Milan, Italy, July 3- 9, 1988, Monduzzi Editore S.p.A.
  • Ricordi, C., Scharp, D.W., Lacy, P.E. - Reversal of diabetes in nude mice after transplantation of fresh and 7 day cultured (24°C) human pancreatic islets, Transplantation 45:994-996, 1988
  • Corlett, M.P., Scharp, D.W., Lacy, P.E. - Microbial contamination risks in human islet isolation, Transplant Proc 20 (Suppl. 1):894-895, 1988
  • Corlett, M.P., Alderson, D., Kneteman, N.M., Scharp, D.W. - Long-term normoglycemia in canine islet autografts, Transplant Proc 20 (Suppl. 1):896-897, 1988
  • Turk, J., Hughes, J.H., Easom, R.A., Wolf, B.A., Scharp, D.W., Lacy, P.E., McDaniel, M.L. - Arachidonic acid metabolism and insulin secretion by isolated human pancreatic islets, Diabetes 37:992-996, 1988
  • Ricordi, C., Lacy, P.E., Finke, E.H., Olack, B.J., Scharp, D.W. - Automated method for isolation of human pancreatic islets, Diabetes 37:413-420, 1988
  • Fonseca, P., Scharp, D.W. - Use of oxygen free radical scavengers to increase the yields of isolated rat islets after pancreatic warm ischemia, Surgical Forum 38:371-373, 1987
  • Kneteman, N.M., Alderson, D., Scharp, D.W. - Long-term normoglycemia in pancreatectomized dogs following pancreatic islet allotransplantation and cyclosporine immunosuppression, Transplantation 44(5):595-599, 1987
  • Scharp, D.W., Lacy, P.E., Finke, E., Olack, B.J. - Low-temperature culture of human islets isolated by the distention method and purified with Ficoll or Percoll gradients, Surgery 102:869-879, 1987
  • Greider, MH, Scharp, DW, Gingerich, RL, Enhanced preservation of endosecretory granules in PP-cells of the canine pancreas. Regulatory peptides 18 (5-6), 299-306, 1987.
  • Kneteman, N.M., Alderson, D., Scharp, D.W. - The isolation and purification of human pancreatic islets, Transplant Proc. 19(4):3469-3470, 1987
  • Alderson, D., Kneteman, N.M., Olack, B.J., Scharp, D.W. - Isolation and quantification of canine islet tissue for transplantation, Transplantation 43(4):579-581, 1987
  • Scharp, D.W., Alderson, D., Kneteman, N.M. - The effect of immunosuppression on islet transplant function in the dog, Transplant Proc. 19(1) 952-953, 1987
  • Hymer, W.C., Scharp, D.W., et al. - Continuous flow electrophoretic separation of proteins and cells from mammalian tissues, Cell Biophysics 10:61-85, 1987
  • Alderson, D., Kneteman, N.M., Scharp, D.W. - The isolation of purified human islets of Langerhans, Transplant Proc. 19(1):916-917, 1987
  • Kneteman, N.M., Alderson, D., Scharp, D.W. - Cyclosporine A immunosuppression of allotransplanted canine pancreatic islets, Transplant. Proc., 19(1):950-951, 1987
  • Scharp, D.W., Alderson, D., Kneteman, N.M. - Optimization of islet preparations for clinical transplantation. Transplant Proc. 18(6):1814-1816, 1986
  • Scharp, D.W., Lacy, P.E., Alderson, D., Kneteman, N.M. - The procurement and distribution of cadaver human pancreas for islet isolation and transplantation. The Use of Human Tissues and Organs for Research and Transplant: Proceedings of the Second I nternational Conference: National Diabetes Research Interchange April 1986:61-70
  • Downing, R., Morrissey, S., Kiske, D., Scharp, D.W. - Does the purity of intraportal islet isografts affect their endocrine function?, J. Surg. Research 41(1):41-46, 1986
  • Scharp, DW, Long, J, Feldmeier, M, Olack, B, O’Shaughnessy, Swansonm, C. Automated Methods of Mass Islet Isolation. Methods in Diabetes Research 1 (Part C), 225-236. 1985
  • Martin, K.W., Morian, J.P., Jr., Lee, J.K.T., Scharp, D.W. - Demonstration of splenic artery pseudoaneurysm by Magnetic Resonance Imaging, J. of Computer Assisted Tomography 9(1):190- 192, 1985
  • Heiken, J.P., Balfe, D.M., Picus, D., Scharp, D.W. - Radical pancreatectomy: Postoperative evaluation by CT, Radiology 153:211-215, 1984
  • Sparks, RE, Mason, NS, Scharp, DW, Some Present Directions in Research on Tissue Transplantation Chambers, Biomaterials in Artificial Organs, 193-199, 1984.
  • Scharp, D.W. - Clinical feasibility of islet transplantation, Transplant Proc. 16(3):820-825, 1984
  • Scharp, D.W., Mason, N.S., Sparks, R.E. - Islet immunoisolation: the use of hybrid artificial organs to prevent islet tissue rejection, World J. of Surgery 8:221-229, 1984
  • Scharp, DW, Transplantation of pancreatic islet cells – Introduction, World Journal of Surgery 8 (2), 135-136, 1984
  • Scharp, D.W. - Isolation and transplantation of islet tissue, World J. of Surgery 8:143- 151,1984
  • Giddings, S.J., Rotwein, P., Chirgwin, J.M., Scharp, D.W., Permutt, M.A. - Analysis of insulin gene expression in human pancreas, Diabetes 32:777-780, 1983
  • Schmidt, R.E., Santiago, B.P., Olack, B.J., Scharp, D.W. - The effect of pancreatic islet t ransplantation and insulin therapy on experimental diabetic autonomic neuropathy, Diabetes 32:532- 540, 1983
  • Sparks, RE, Mason, TC, Scharp, DW, A distributed source-model for the hybrid artificial pancreas, ASAIO Journal 29 (1), 460-462, 1983.
  • Long, J.A., Britt, L.D., Olack, B.J., Scharp, D.W. - Autotransplantation of isolated canine islets, Transplant Proc. 15:1332-1338, 1983
  • Scharp, D.W., Long, J.A. - Studies of islet isolation and transplantation, Cryobiology 20:129-137, 1983
  • Scharp, DW, Long, JA, Olack, BA, Preparation of pseudo-islets, Cryobiology 19 (6), 659- 660, 1982.
  • Scharp, DW, Lacy, PE, The isolation and alteration of islet tissue for transplantation. In Vitro – Journal of the Tissue Culture Association. 18 (3), 316-317, 1982.
  • Britt, L.D., Scharp, D.W., Lacy, P.E., Slavin, S., Transplantation of islet cells across major histocompatibility barriers after total lymphoid irradiation and infusion of allogeneric bone marrow cells, Diabetes 31 Aupp 4), 63-68, 1982.
  • Gingerich, R.L., Scharp, D.W., Grieder, M.H., Dye, E.S., Mousel, K.A. - A new in vitro model for studies of pancreatic polypeptide secretion and biochemistry, Regulatory Peptides 5:13-25, 1982
  • Sparks, R.E., Mason, N.S., Finley, T.C., Scharp, D.W., Development, testing, and modeling of an islet transplantation chamber, ASAIO Journal 28 91), 229-231, 1982.
  • Yasunami, Y., Lacy, P.E., Scharp, D.W., Britt, L.D. - Isolation and transplantation of islet cells from the neonatal pig pancreas, Surgical Forum 33, 359-361, 1982
  • Schmidt, R.E., Scharp, D.W. - Axonal dystrophy in experimental diabetic autonomic neuropathy, Diabetes 31:761-770, 1982
  • Greider, MH, Gingerich, RL, Scharp, DW, in vitro studies of canine pseudo-islets, Cellular Basis of Chemical Messengers in the Digestive System, 317-321, 1981
  • Paquette, T.L., Gingerich, R., Scharp, D.W. - Altered amidation of pancreatic polypeptide in culture, Biochemistry 20:7403-7408, 1981
  • Scharp, DW, Rejection of islet isografts in a strain of Lewis rats, Transplantation 31 (3) 229- 230, 1981.
  • Bergen, J., Mason, N.S., Scharp, D.W., Sparks, R.E. - Insulin inhibition of islets in transplantation chambers, Artificial Organs 5:787-791, 1981
  • Britt, L.D., Scharp, D.W., Lacy, P.E., Slavin, S. - Transplantation of islet cells across major histocompatibility barriers after total lymphoid irradiation and infusion of allogeneic bone marrow cells, Diabetes 31:36-38, 1982
  • Silberberg,R, Scharp, DW, LEsker, PA. Biochemical Studies of Long Bone from Diabetic Rats and Rats Bearing Transplanted Pancreatic Islets.,Pathobiology 49(2) 61-67.
  • Britt, L.D., Stojeba, P.C., Scharp, C.R., Grieder, M.H., Scharp, D.W. - Neonatal pig pseudoislets: A product of selective aggregation, Diabetes 30:580-583, 1981
  • Britt, L.D., Stojeba, P.C., Scharp, C.R., Grieder, M.H., Scharp, D.W. - Neonatal pig pseudoislets: A product of selective aggregation, Diabetes 30:580-583, 1981
  • Rajotte, R.V., Scharp, D.W., Downing, R., Preston, R., Molnar, G.D., Ballinger, W.F. - Pancreatic islet banking: the transplantation of frozen-thawed rat islets transported between Centers, Cryobiology 18:357-369, 1981
  • Silberberg, R., Scharp, D.W., Lesker, P.A. - Biochemical studies of bone from diabetic rats and rats bearing transplanted pancreatic islets, Experimental Cell Biology 49:61-67, 1981
  • RV Rajotte, DW Scharp, R Downing, P Preston, GD Molnar, WF Ballinger, Transplantation of frozen-thawed rat islets of Lanagerhans after sucrose versus step dilution, Cryobiology 17 (6), 618-619, 1981.
  • Grieder, M.H., Gingerich, R.L., Scharp, D.W. - In Vitro studies of canine pseudo-islets. UCLA Symposium - Cellular Basis of Chemical Messengers in the Digestive System”, Los Angeles, January 16-18, 1980
  • Downing, R., Scharp, D.W., Ballinger, W.F., An improved technique for the isolation and identification of mammalian islets of Langerhans, Transplantation 29(1), 79.82, 1980.
  • Feldman, S.D., Scharp, D.W., Lacy, P.E., Ballinger, W.F. - Fetal pancreas isografts, cultured and uncultured, to reverse streptozotocin induced diabetes mellitus, J. Surgical Research 29:309-318, 1980
  • Merrell, R.C., Scharp, D.W., Gingerich, R., Feldmeier, M.M., Grieder, M., Downing, R. - New approaches to the separation of islet cells, Surgical Forum 30:303-305, 1979
  • Downing, R., Scharp, D.W., Merrell, R.C., Grieder, M., Ballinger, W.F. - Venous versus ductal distension of the dog pancreas for isolation of islets, Surgical Forum 30:422-424, 1979
  • Scharp, D.W., Downing, R., Merrell, R.C., Grieder, M. - Isolating the elusive islet, Diabetes 29(1):19- 30, 1980
  • Lacy, P.E., Davie, J.M., Finke, E.H., Scharp, D.W. - Prolongation of islet allograft survival, Transplantation 27:171-174, 1979
  • Downing, R., Scharp, D.W., Ballinger, W.F. - An improved technique for the isolation and identification of mammalian islets of Langerhans, Transplantation 29:79-83, 1980
  • Merrell, RC, Scharp, DW, Gingerich, R, Feldmeier, M, Greider, M, Downing, R. New Approaches to Separation of Islet Cells. Surgical Forum 30. 301-305, 1978.
  • Downing, R., Scharp, D.W., Merrell, R., Greideer, M., Ballinger, W.F. Venous versus ductal distension of the canine pancreas for isolation of islets, Surgical Forum 30:422-424, 1979.
  • Scharp,DW, Merrell, RC, Feldmeier, MM, Downing, R, Ballinger, WG.Pseudo-islet Formation and Culture from Canine Isolated Pancreatic Cells. InVitro Journal Tissue Culture Association 15(3) 216, 1979
  • Krupin, T., Waltman, S.R., Scharp, D.W., Oestrich, G., Feldman, S.D., Becker, D., Ballinger, W.F., Lacy, P.E. - Ocular fluorophotometry in experimental diabetes mellitus: The effect of pancreatic islet isografts, Investigative Ophthalmology & Visual Science 18:1185-190, 1979
  • Scharp, D, Krupin, T, Waltman, S, Oestrich, C, Feldman, S, Ballinger, W ... Relationship of abnormal insulin release to fluorophotometry in experimental diabetes, Diabetes 27, 435-435, 1978.
  • Scharp, D, Krupin, T, Waltman, S, Oestrich, C, Feldman, S, Ballinger, W ... Relationship of abnormal insulin release to fluorophotometry in experimental diabetes, Diabetes 27, 435-435, 1978.
  • Scharp, D.W., Merrell, R.C., Feldman, S.D., Downing, R., Lacy P,E., Ballinger, W. - The use of gyrotational culture for the preservation of isolated islets, Surgical Forum 29:100- 102, 1978
  • Feldman, S, Dodi, G, Haid, K, Scharp, DW, Ballinger, WF, Lacy, PE, Artificial hybrid pancreas, Surgical Forum 28:439-441, 1977
  • Feldman, S., Scharp, D., Hirshberg, G., Dodi, G., Ballinger, W., Lacy, P.E. - Streptozotocininduced liver tumors, Transplantation 24:152-154, 1977
  • Griffith, R.C., Scharp, D.W., Hartman, B.K., Ballinger, W.F., Lacy, P.E. - A morphologic study of intrahepatic portal vein islet isografts, Diabetes 26:201-214, 1977
  • Scharp, DW, Merrell, RC, Feldman SD, Ruwe, EA, Feldmeier, M. Long-Term Culture of Islets of Langerhans Utilizing a Rotational Culture Method. In Vitro- Journal of Tissue Culture Association.13 (3), 174.
  • Karl, R.C., Scharp, D.W., Ballinger, W.F., Lacy, P.E. - Transplantation of insulin-secreting tissues, J British Society Gastroenterology - GUT 18:1062-1072, 1977
  • Feldman, S., Hirshberg, G., Dodi, G., Raizman, M., Scharp, D., Ballinger, W., Lacy, P.E. - Intrasplenic islet isografts, Surgery 82:386-394, 1977
  • Scharp, D.W., Murphy, J.J., Newton, W.T., Ballinger, W.F., Lacy, P.E. - Application of an improved isolation technique for islet transplantation in primates and rats, Transplant. Proc. 6(1):739-741, 1975
  • Scharp, D.W., Murphy, J.J., Newton, W.T., Ballinger, W.F., Lacy, P.E. - Transplantation of islets of Langerhans in diabetic Rhesus monkeys, Surgery 77:100-105, 1975
  • MJ Knight, DW Scharp, CB Kemp, SB Nunnelly, Ballinger WF, PE Lacy, Cryopreservation of pancreatic islets. European Surgical Research, 6, 89-89, 1974.
  • DW Scharp, CB Kemp, MJ Knight, JJ Murphy, WT Newton, WF Ballinger, ... Long-term results of portal vein islet isografts and allografts in treatment of streptozotocin-induced diabetes, Diabetes 23, 359-359, 1974.
  • Ballinger, WF, Lacy, PE, Scharp. DW, Kemp, CB, Knight, M- Isografts and Allografts of Pancreatic Islets in Rats. British J Surgery, 60(4): 313, 1973
  • Ballinger, WF, Lacy, PE, Scharp. DW, Kemp, CB, Knight, M- Isografts and Allografts of Pancreatic Islets in Rats. British J Surgery, 60(4): 313, 1973
  • Kemp, C.B., Knight, M.J., Scharp, D.W., Ballinger, W.F., Lacy, P.E. - Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats, Diabetologia 9:489-491, 1973
  • Scharp, D.W., Kemp, C.B., Knight, M.J., Ballinger, W.F., Lacy, P.E. - The use of Ficoll in the preparation of viable islets of Langerhans from the rat pancreas, Transplantation 16:686-689, 1973
  • Kemp, C.B., Knight, M.J., Scharp, D.W., Lacy, P.E., Ballinger, W.F. - Transplantation of isolated pancreatic islets into the portal vein of diabetic rats, Nature 244:447, 1973
  • Kemp, C.B., Scharp, D.W., Knight, M.J., Ballinger, W.F., Lacy, P.E. - Importance of implantation site of pancreatic islet isografts in treatment of experimental diabetes, Surgical Forum 24:297-299, 1973
  • Knight, M.J., Scharp, D.W., Kemp, C.B., Ballinger, W.F., Lacy, P.E. - Effects of cold storage on the function of isolated pancreatic islets, Cryobiology, 10:89-90, 1973
  • Merrick, A.W., Scharp, D.W. - Electroencephalography of resting behavior in cattle, with observations on the question of sleep, Am. J. Vet. Res., 32:1893-1897, 1971
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